| Size | Price | |
|---|---|---|
| 250mg | ||
| 500mg | ||
| Other Sizes |
| Targets |
H-Gly-Gly-Pro-OH does not have a defined pharmacological target. It is a peptide fragment and an end product of collagen metabolism. The compound is further cleaved by the enzyme prolidase. It is used as a research tool for studying collagen turnover and peptide biochemistry.
|
|---|---|
| ln Vitro |
In vitro, H-Gly-Gly-Pro-OH is used in biochemical research and peptide synthesis. It provides insights into the behavior of larger protein structures. The compound is a substrate for the enzyme prolidase, which cleaves the peptide bond between glycine and proline. No other specific in vitro activities have been reported.
|
| ln Vivo |
In vivo activity of H-Gly-Gly-Pro-OH has not been extensively characterized. As an end product of collagen metabolism, it is a natural metabolite present in the body. However, specific pharmacological effects have not been reported. The compound is primarily used as a research tool for in vitro studies.
|
| Enzyme Assay |
In vitro enzyme/receptor binding assays for H-Gly-Gly-Pro-OH typically involve studying its cleavage by prolidase. The compound is incubated with purified prolidase enzyme in appropriate buffer, and the cleavage products (glycine and proline) are quantified using HPLC or colorimetric assays. Kinetic parameters such as Kₘ and Vₘₐₓ can be determined.
|
| Cell Assay |
In vitro cell-based assays for H-Gly-Gly-Pro-OH are not typically performed, as the compound is not a bioactive molecule with specific cellular activities. It is used as a substrate in enzymatic assays and as a reference standard in peptide chemistry.
|
| Animal Protocol |
In vivo animal studies are not applicable to H-Gly-Gly-Pro-OH. The compound is a natural metabolite and a research tool for in vitro studies. It is not administered to animals for therapeutic or pharmacological research purposes.
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| ADME/Pharmacokinetics |
Pharmacokinetic (PK) properties of H-Gly-Gly-Pro-OH have not been characterized, as it is not a therapeutic agent. The compound is a natural metabolite and a research tool. Its PK properties are not relevant to its intended applications.
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| Toxicity/Toxicokinetics |
The toxicity profile of H-Gly-Gly-Pro-OH has not been characterized. As a natural tripeptide derived from collagen metabolism, it is generally considered to have low toxicity. No specific toxicology data are available. The compound is intended for research use only.
|
| Additional Infomation |
H-Gly-Gly-Pro-OH is a research-grade tripeptide used in biochemical research and peptide synthesis. It is an end product of collagen metabolism and a substrate for prolidase. The compound is not an approved therapeutic drug. It is supplied as a powder with high purity. Synonyms include Glycyl-glycyl-L-proline.
|
| Molecular Formula |
C9H15N3O4
|
|---|---|
| Molecular Weight |
229.2331
|
| Exact Mass |
229.106
|
| CAS # |
14379-76-1
|
| PubChem CID |
263467
|
| Appearance |
White to off-white solid powder
|
| Density |
1.381g/cm3
|
| Boiling Point |
588.4ºC at 760mmHg
|
| Flash Point |
309.6ºC
|
| Vapour Pressure |
2.28E-15mmHg at 25°C
|
| Index of Refraction |
1.561
|
| LogP |
-4
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
16
|
| Complexity |
305
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
NCC(NCC(N1CCCC1C(O)=O)=O)=O
|
| InChi Key |
BUEFQXUHTUZXHR-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H15N3O4/c10-4-7(13)11-5-8(14)12-3-1-2-6(12)9(15)16/h6H,1-5,10H2,(H,11,13)(H,15,16)
|
| Chemical Name |
1-[2-[(2-aminoacetyl)amino]acetyl]pyrrolidine-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~436.24 mM)
DMSO : ≥ 2.5 mg/mL (~10.91 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (436.24 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3624 mL | 21.8122 mL | 43.6243 mL | |
| 5 mM | 0.8725 mL | 4.3624 mL | 8.7249 mL | |
| 10 mM | 0.4362 mL | 2.1812 mL | 4.3624 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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