| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
H-Glu-Gly-OH targets excitatory amino acid receptors as an antagonist. Its structure is similar to GABA (γ-aminobutyric acid), which allows it to interact with excitatory amino acid signaling pathways. It does not have a therapeutic target but is a research tool for studying excitatory amino acid neurotransmission and metabolism. Its primary value is as a research reagent for studying glutamate and GABA signaling.
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| ln Vitro |
γ-Glu-Gly is a crucial factor influencing how mature cheese tastes. Two γ-glutamyl peptides, γ-Glu-Glu and γ-Glu-Gly, are produced by Saccharomyces cerevisiae's γ-glutamyl transferase (GGT) [1].
In vitro, H-Glu-Gly-OH is used to study its activity as an antagonist of excitatory amino acids. It is used in biochemical assays to investigate the role of excitatory amino acids in neurotransmission and metabolism. The compound may be used as a standard in analytical methods for detecting γ-glutamyl dipeptides. It is also used as a diagnostic reagent. Its role in research is in neurobiology and metabolism. |
| ln Vivo |
H-Glu-Gly-OH is not a pharmacologically active drug but has been studied for its in vivo effects as an antagonist of excitatory amino acids. It is a human lipid metabolite. When administered to animals, it may modulate excitatory amino acid signaling due to its structural similarity to GABA. Its primary value is in research, particularly in the fields of neurobiology and metabolism, where it serves as a tool for studying excitatory amino acid function and GABAergic signaling.
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| Enzyme Assay |
In vitro assays for H-Glu-Gly-OH are designed to study its activity as an antagonist of excitatory amino acids. A standard protocol involves using receptor binding or functional assays to assess the compound's interaction with excitatory amino acid receptors. The compound's ability to inhibit the effects of excitatory amino acids is measured. These assays are used to characterize the compound's activity and to study excitatory amino acid signaling.
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| Cell Assay |
In vitro cellular assays using H-Glu-Gly-OH are conducted to study its effects on excitatory amino acid signaling. Neuronal cell cultures are treated with the compound, and its effects on neuronal activity, calcium signaling, or neurotransmitter release are measured. The compound's ability to antagonize the effects of excitatory amino acids is assessed. These experiments help to elucidate the role of γ-glutamyl peptides in neurotransmission.
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| Animal Protocol |
In vivo animal studies with H-Glu-Gly-OH are not typically conducted for therapeutic purposes. However, it may be used in studies of excitatory amino acid signaling and metabolism. A typical protocol involves administration of the compound to rodents, followed by behavioral or physiological assessments. Its effects on seizure activity or other excitatory amino acid-mediated responses may be evaluated. These studies help to understand the role of γ-glutamyl peptides in the brain.
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| ADME/Pharmacokinetics |
As a small, hydrophilic dipeptide, H-Glu-Gly-OH is expected to be rapidly metabolized in the body. Its pharmacokinetic properties are characteristic of small peptides, with rapid clearance and short half-life. Detailed pharmacokinetic data are not typically reported, as the compound is used primarily as a research reagent rather than a drug candidate.
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| Toxicity/Toxicokinetics |
H-Glu-Gly-OH is generally considered to have low toxicity, consistent with its status as an endogenous metabolite. It is a human lipid metabolite. Standard laboratory safety precautions, including the use of personal protective equipment, are recommended. No significant systemic toxicity is anticipated at typical research doses.
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| References |
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| Additional Infomation |
γ-Glutamic acid (Gamma-Glu-Gly) is a glutamyl-L-amino acid formed by the condensation of the γ-carboxyl group of glutamic acid and the amino group of glycine. It is a human metabolic product and the conjugate acid of γ-glutamylglycine (1-). It has been reported that 5-L-glutamylglycine is present in Agaricus bisporus, Dietes iridioides, and other organisms with relevant data.
H-Glu-Gly-OH (γ-Glutamylglycine, CAS 1948-29-4) is a γ-glutamyl dipeptide composed of glutamic acid and glycine. Its molecular formula is C₇H₁₂N₂O₅ and its molecular weight is 204.18 g/mol. It is a human lipid metabolite. It is structurally similar to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids. It is used as a diagnostic reagent and is intended for research use only. |
| Molecular Formula |
C7H12N2O5
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|---|---|
| Molecular Weight |
204.18058
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| Exact Mass |
204.075
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| CAS # |
1948-29-4
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| PubChem CID |
165527
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| Appearance |
White to off-white solid powder
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| Density |
1.424g/cm3
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| Boiling Point |
586.6ºC at 760mmHg
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| Flash Point |
308.6ºC
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| Vapour Pressure |
2.78E-15mmHg at 25°C
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| Index of Refraction |
1.536
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| LogP |
-4.3
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
14
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| Complexity |
240
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C(CC(=O)NCC(=O)O)[C@@H](C(=O)O)N
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| InChi Key |
ACIJGUBIMXQCMF-BYPYZUCNSA-N
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| InChi Code |
InChI=1S/C7H12N2O5/c8-4(7(13)14)1-2-5(10)9-3-6(11)12/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14)/t4-/m0/s1
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| Chemical Name |
(2S)-2-amino-5-(carboxymethylamino)-5-oxopentanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~5 mg/mL (~24.49 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (244.88 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8976 mL | 24.4882 mL | 48.9764 mL | |
| 5 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | |
| 10 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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