Size | Price | Stock | Qty |
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500mg |
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Other Sizes |
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Targets |
Human Endogenous Metabolite
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ln Vitro |
D-leucine did not compete with cognate ligand binding in a screen of potential neural receptors, which would indicate a different target. D-leucine suppresses continuing seizures at least as well as diazepam, even at modest doses. According to these results, D-leucine might be a member of a novel class of antiepileptic medications and might have uses in eukaryotes that have not been discovered before [1].
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References |
[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193
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Molecular Formula |
C6H13NO2
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Molecular Weight |
131.17292
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Exact Mass |
131.09
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CAS # |
328-38-1
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Related CAS # |
D-Leucine-d10; 271247-12-2
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Appearance |
White to off-white powder
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SMILES |
CC(C)C[C@H](C(=O)O)N
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InChi Key |
ROHFNLRQFUQHCH-RXMQYKEDSA-N
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InChi Code |
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1
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Chemical Name |
(2R)-2-amino-4-methylpentanoic acid
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Synonyms |
(R)-Leucine; D-Leucine; H-D-Leu-OH
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~10 mg/mL (~76.24 mM)
DMSO :< 1 mg/mL |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 7.6237 mL | 38.1185 mL | 76.2369 mL | |
5 mM | 1.5247 mL | 7.6237 mL | 15.2474 mL | |
10 mM | 0.7624 mL | 3.8118 mL | 7.6237 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.