| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
Biochemical factor Stk1 (GW779439X, 2 μM). Ceftaroline's efficacy against MRSA strains resistant to ceftaroline is boosted by GW779439X (5 μM). Oxacillin's efficacy against a range of isolates of Staphylococcus aureus, including MRSA and MSSA isolates, is boosted by GW779439X. GW779439X inhibits the growth of the AGP-01 cell line (IC50 = 0.57 μM). PBP2A-containing solutions exhibit the strongest enhancement effect of GW779439X (1 μM), which significantly fluctuates the G0/G1 phase and sub-G1 [1]. Genes associated with proliferation progression (c-MYC, NRAS, and CDC25A) exhibit significantly lower expression levels when exposed to 1 μM of GW779439X for 72 hours in AGP-01 cells. Conversely, genes associated with cell cycle arrest (TP53 and CDKN1A) exhibit significantly higher expression levels [2].
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| References |
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| Molecular Formula |
C22H21F3N8
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|---|---|
| Molecular Weight |
454.450953245163
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| Exact Mass |
454.184
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| CAS # |
551919-98-3
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| PubChem CID |
10173796
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| Appearance |
White to light brown solid powder
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| Density |
1.5±0.1 g/cm3
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| Index of Refraction |
1.680
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| LogP |
4.03
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
10
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
33
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| Complexity |
644
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZOTNSCLLJKXGSD-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C22H21F3N8/c1-31-9-11-32(12-10-31)20-5-4-15(13-17(20)22(23,24)25)29-21-26-8-6-18(30-21)16-14-28-33-19(16)3-2-7-27-33/h2-8,13-14H,9-12H2,1H3,(H,26,29,30)
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| Chemical Name |
N-[4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~31.25 mg/mL (~68.76 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.58 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2005 mL | 11.0023 mL | 22.0046 mL | |
| 5 mM | 0.4401 mL | 2.2005 mL | 4.4009 mL | |
| 10 mM | 0.2200 mL | 1.1002 mL | 2.2005 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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