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|---|---|---|
| Other Sizes |
| ln Vitro |
Three different phosphorylated forms of guanosine include guanosine monophosphate (GMP), guanosine triphosphate (GTP), cyclic guanosine monophosphate (cGMP), and guanosine diphosphate (GDP). These forms are essential for many metabolic processes, including the production of proteins and nucleic acids, photosynthesis, contraction of muscles, and intracellular signal transduction (cGMP).
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| References | |
| Additional Infomation |
Guanosine is a purine nucleoside in which guanine is linked to ribofuranose via a β-N(9)-glycosidic bond. It is an important metabolite. Guanosine belongs to the purine D-ribonucleotide class and is a member of the guanosine group. It is functionally related to guanine. Guanosine is a nucleoside formed by guanine being linked to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to produce GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate), all of which are factors in signal transduction pathways. Guanosine is a metabolite present in or produced by Escherichia coli (K12 strain, MG1655 strain). Ribonucleotides are metabolites present in or produced by Escherichia coli (K12 strain, MG1655 strain).
Guanosine has also been reported in Daphnia pulex, Sinocrassula indica, and other organisms with relevant data. Guanosine is a purine nucleoside composed of guanine and a ribose ring linked by a β-N9-glycosidic bond, and is essential for metabolism. Guanosine is found in or produced by Saccharomyces cerevisiae. Saccharomyces cerevisiae is a purine nucleoside in which guanine is linked to the C1 carbon atom of the ribose through its N9 nitrogen atom. It is a component of ribonucleic acid (RNA), and its nucleotides play an important role in metabolism. (Excerpt from Dorland, 28th edition) |
| Molecular Formula |
C10H13N5O5
|
|---|---|
| Molecular Weight |
283.2407
|
| Exact Mass |
283.091
|
| CAS # |
118-00-3
|
| Related CAS # |
Guanosine-8-d-1;Guanosine-15N5
|
| PubChem CID |
135398635
|
| Appearance |
White to off-white solid powder
|
| Density |
2.3±0.1 g/cm3
|
| Boiling Point |
756.6±70.0 °C at 760 mmHg
|
| Melting Point |
240ºC
|
| Flash Point |
411.4±35.7 °C
|
| Vapour Pressure |
0.0±2.7 mmHg at 25°C
|
| Index of Refraction |
1.955
|
| LogP |
-1.9
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
20
|
| Complexity |
446
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
O1[C@]([H])(C([H])([H])O[H])[C@]([H])([C@]([H])([C@]1([H])N1C([H])=NC2C(N([H])C(N([H])[H])=NC1=2)=O)O[H])O[H]
|
| InChi Key |
NYHBQMYGNKIUIF-UUOKFMHZSA-N
|
| InChi Code |
InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
|
| Chemical Name |
2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
|
| Synonyms |
NSC19994; NSC 19994; Guanosine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 75 mg/mL (~264.79 mM)
H2O : ~1 mg/mL (~3.53 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 3.33 mg/mL (11.76 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 33.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5306 mL | 17.6529 mL | 35.3057 mL | |
| 5 mM | 0.7061 mL | 3.5306 mL | 7.0611 mL | |
| 10 mM | 0.3531 mL | 1.7653 mL | 3.5306 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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