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    GSTO1-IN-1
    GSTO1-IN-1

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4571
    CAS #: 568544-03-6Purity ≥98%

    Description: GSTO1-IN-1, a chloroacetamide-containing compound, is a novel and potent glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50 of 31 nM. Glutathione S-transferase omega 1 (GSTO1) is an atypical GST isoform that is overexpressed in several cancers and has been implicated in drug resistance. Currently, no small-molecule drug targeting GSTO1 is under clinical development. Co-crystal structures of GSTO1 with GSTO1-IN-1 demonstrate covalent binding to the active site cysteine. These potent GSTO1 inhibitor GSTO1-IN-1 suppresses cancer cell growth, enhance the cytotoxic effects of cisplatin and inhibit tumour growth in colon cancer models as single agent. Bru-seq-based transcription profiling unravelled novel roles for GSTO1 in cholesterol metabolism, oxidative and endoplasmic stress responses, cytoskeleton and cell migration.These findings demonstrate the therapeutic utility of GSTO1 inhibitors as anticancer agents and identify the novel cellular pathways under GSTO1 regulation in colorectal cancer.

    References 2016 Oct 5;7:13084.


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    GSTO1-IN-1

    Molecular Weight: 311.18
    Formula: C₁₀H₁₂Cl₂N₂O₃S
    CAS No.: 568544-03-6
    SMILES: O=C(NC1=CC=C(Cl)C(S(=O)(N(C)C)=O)=C1)CCl
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationGSTO1-IN-2; GSTO1 IN2; GSTO1 IN-2


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    GSTO1-IN-1


    Identification and characterization of C1-27 as a potent GSTO1 inhibitor.  2016 Oct 5;7:13084.

     GSTO1-IN-1


    GSTO1 inhibition impedes cancer cell viability.  2016 Oct 5;7:13084.

     GSTO1-IN-1


    C1-27 inhibits colorectal cancer tumour growth in vivo.  2016 Oct 5;7:13084.

    GSTO1-IN-1


    C1-27 is a covalent GSTO1 inhibitor.  2016 Oct 5;7:13084.

     GSTO1-IN-1


    Analysis of gene expression following C1-27 treatment and GSTO1 knockdown.  2016 Oct 5;7:13084.



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