| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
GSK726701A exhibits no discernible activity against a wider variety of targets and is extremely selective (>100-fold) against a panel of additional prostaglandin receptors (EP1-3, DP1, FP, IP, TP). In a human whole blood (HWB) experiment, it showed EP4 agonist action with equal potency and intrinsic activity (pEC50=8.2), blocking LPS-mediated TNFα production [1].
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|---|---|
| ln Vivo |
There is strong pharmacokinetic evidence for GSK726701A in rats, dogs, and monkeys. Animal models of inflammatory and neuropathic pain are highly responsive to GSK726701A. At a dose of 3 mg/kg, which is comparable to the clinical gold standard of 30 mg/kg gabapentin, GSK726701A totally reverses mechanical allodynia caused by CCI. In the FCA acute inflammatory pain rat model, GSK726701A has an ED50 of 0.2 mg/kg[1].
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| References |
| Molecular Formula |
C24H22FNO5
|
|---|---|
| Molecular Weight |
423.43359041214
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| Exact Mass |
423.148
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| CAS # |
945721-87-9
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| PubChem CID |
16678098
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| Appearance |
White to off-white solid powder
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| LogP |
4
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
31
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| Complexity |
660
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(CC1C(F)=CC(N2CC3C(=C(C4C(C=3OCC)=CC=CC=4)OCC)C2=O)=CC=1)O
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| InChi Key |
YJEFCZJZEASKIO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C24H22FNO5/c1-3-30-22-16-7-5-6-8-17(16)23(31-4-2)21-18(22)13-26(24(21)29)15-10-9-14(11-20(27)28)19(25)12-15/h5-10,12H,3-4,11,13H2,1-2H3,(H,27,28)
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| Chemical Name |
2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-2-fluorophenyl]acetic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~59.04 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.90 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3617 mL | 11.8083 mL | 23.6167 mL | |
| 5 mM | 0.4723 mL | 2.3617 mL | 4.7233 mL | |
| 10 mM | 0.2362 mL | 1.1808 mL | 2.3617 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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