| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
GPRP acetate (0, 2 and 4 mM) stimulates oxidant enzyme production [1].
|
|---|---|
| ln Vivo |
By promoting weight loss and engraftment, GPRP acetate (100 mg/kg; intraperitoneally, once daily for 10 days) dramatically lowers glucose enzyme sodium sulfate (DSS)-induced inflammation [3].
|
| Animal Protocol |
Animal/Disease Models: C57BL/6 mice dextran sodium sulfate (DSS)-induced colitis [3]
Doses: 100 mg/kg Route of Administration: intraperitoneal (ip) injection; 100 mg/kg, one time/day for 10 days Experimental Results: Significant Dramatically inhibited weight loss in colitis mice, diminished DSS-induced mortality and colon length shortening, and diminished tissue damage and inflammatory cell infiltration. Mice with colitis have diminished levels of inflammatory cytokines. |
| References |
| Molecular Formula |
C20H35N7O7
|
|---|---|
| Molecular Weight |
485.5346
|
| Exact Mass |
485.259
|
| CAS # |
157009-81-9
|
| Related CAS # |
GPRP;67869-62-9
|
| PubChem CID |
118986652
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
6
|
| Hydrogen Bond Acceptor Count |
9
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
34
|
| Complexity |
725
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
CC(=O)O.C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)O
|
| InChi Key |
ZYTSTPIIKNCGRE-QKWXXBCPSA-N
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| InChi Code |
InChI=1S/C18H31N7O5.C2H4O2/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30;1-2(3)4/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22);1H3,(H,3,4)/t11-,12-,13-;/m0./s1
|
| Chemical Name |
acetic acid;(2S)-1-[(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~125 mg/mL (~268.93 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (215.14 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0596 mL | 10.2980 mL | 20.5960 mL | |
| 5 mM | 0.4119 mL | 2.0596 mL | 4.1192 mL | |
| 10 mM | 0.2060 mL | 1.0298 mL | 2.0596 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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