| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg | |||
| Other Sizes |
| Targets |
GPR120 modulator 2 targets GPR120 (FFAR4), a receptor for long-chain fatty acids. By modulating GPR120 activity, this compound can enhance fatty acid-mediated signaling, reduce proinflammatory cytokine production, and improve glucose homeostasis. It is widely used in research to study metabolic disorders.
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| ln Vitro |
In vitro studies demonstrate that GPR120 modulator 2 is useful for modulating GPR120 activity. By enhancing fatty acid-mediated signaling and reducing proinflammatory cytokine production, it helps elucidate the role of GPR120 in metabolic and inflammatory pathways. Its activity is typically assessed in cell-based assays measuring downstream signaling.
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| ln Vivo |
In vivo, GPR120 modulator 2 has shown efficacy in preclinical models of metabolic disorders. By modulating GPR120, it can improve glucose homeostasis, making it a valuable tool for studying potential therapeutic strategies for obesity, diabetes, and inflammation.
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| Enzyme Assay |
In vitro receptor binding assays for GPR120 modulator 2 are performed to measure its affinity for GPR120. These assays typically involve competitive displacement of a labeled ligand from the receptor using membranes from cells expressing human GPR120. Its modulatory activity is confirmed in functional assays measuring downstream signaling pathways.
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| Cell Assay |
Cellular assays for GPR120 modulator 2 are conducted using cell lines expressing GPR120 to evaluate its effects on receptor signaling. Cells are treated with the compound, and downstream signaling events, such as the reduction of proinflammatory cytokine production, are measured. These assays help define the compound's mechanism of action.
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| Animal Protocol |
In vivo animal studies for GPR120 modulator 2 are conducted in models of metabolic disorders such as diabetes and obesity. Animals are treated with the compound, and endpoints such as glucose tolerance, insulin sensitivity, and inflammatory markers are assessed to evaluate its therapeutic potential.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of GPR120 modulator 2 are characteristic of a small molecule. It has a molecular weight of 387.88 and a molecular formula of C20H18ClNO3S. It is soluble in DMSO and is typically stored at -20degC. It can be formulated for in vivo administration.
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| Toxicity/Toxicokinetics |
The toxicological profile of GPR120 modulator 2 is not fully detailed. As a research compound, its safety is primarily evaluated in preclinical studies. It is for research use only and is not for human therapeutic use. Standard safety precautions should be followed.
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| References | |
| Additional Infomation |
GPR120 modulator 2 is a tool compound for studying GPR120 (FFAR4) and its role in metabolic and inflammatory diseases. It has potential therapeutic applications for obesity, diabetes, and inflammation. It is available for research use only and is not for therapeutic use.
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| Molecular Formula |
C20H18CLNO3S
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|---|---|
| Molecular Weight |
387.879823207855
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| Exact Mass |
387.07
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| CAS # |
1050506-87-0
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| PubChem CID |
25017837
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| Appearance |
White to off-white solid powder
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| LogP |
5.368
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
26
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| Complexity |
466
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
PNGZPTUFKSLWEZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H18ClNO3S/c1-13-10-15(8-6-14(13)7-9-20(23)24)25-11-19-22-18(12-26-19)16-4-2-3-5-17(16)21/h2-6,8,10,12H,7,9,11H2,1H3,(H,23,24)
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| Chemical Name |
3-[4-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]methoxy]-2-methylphenyl]propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~257.81 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3 mg/mL (7.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3 mg/mL (7.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 30.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5781 mL | 12.8906 mL | 25.7812 mL | |
| 5 mM | 0.5156 mL | 2.5781 mL | 5.1562 mL | |
| 10 mM | 0.2578 mL | 1.2891 mL | 2.5781 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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