| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
| Targets |
Glyceryl monocaprate does not have a specific single molecular target but acts as an antimicrobial agent. Its mechanism involves disruption of microbial cell membranes due to its surfactant properties. It is effective against enveloped viruses, Gram-positive bacteria, and Candida albicans.
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|---|---|
| ln Vitro |
Launched ATCC SA 29123 [1], glyceryl monocaprate (Monolaurin) has antibacterial activity and is effective against Gram.
Glyceryl monocaprate has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. It has an inhibitory effect on Herpes Simplex Virus (HSV). As a monoglyceride, it disrupts microbial membranes through its amphiphilic properties. |
| ln Vivo |
In comparison to monolaurin and glyceryl monolaurate alone, glyceryl monolaurin) coupled with low-dose doxycycline is effective in treating cold sores, resulting in a much longer overall treatment time and less pain [2].
Glyceryl monocaprate (Monolaurin) combined with low-dose doxycycline offers an effective treatment for herpes labialis, significantly reducing time to healing and pain compared with placebo and monocaprin alone. This demonstrates its in vivo efficacy as an antiviral agent. |
| Enzyme Assay |
In vitro antimicrobial assays for Glyceryl monocaprate involve measuring its inhibitory effects on microbial growth. Bacteria or fungi are cultured in the presence of varying concentrations of the compound, and the minimum inhibitory concentration (MIC) is determined. For antiviral activity, virus-infected cells are treated with the compound, and viral replication is measured.
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| Cell Assay |
In vitro cell-based assays for Glyceryl monocaprate assess its antiviral and antimicrobial activity in cell culture systems. For HSV, cells are infected with the virus and treated with Glyceryl monocaprate, and viral titer or plaque formation is measured. Its effects on bacterial and fungal growth can also be assessed in culture.
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| Animal Protocol |
In vivo studies of Glyceryl monocaprate have been conducted in models of herpes labialis. The compound is typically applied topically, and endpoints include time to healing, pain reduction, and lesion resolution.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Glyceryl monocaprate are not extensively reported. As a topical agent, systemic absorption is limited. When used orally or topically, it is metabolized as a fatty acid ester. Its use in cosmetics and food suggests a favorable safety profile.
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| Toxicity/Toxicokinetics |
Glyceryl monocaprate is generally recognized as safe for use in cosmetics, pharmaceuticals, and food. In skincare, it is valued for its moisturizing and softening effects without causing irritation. At antimicrobial concentrations, it is well-tolerated.
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| References |
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| Additional Infomation |
1-Monodecanoylglycerol is a 1-monoglyceride with a decanoyl (octanoyl) acyl group. It is both a 1-monoglyceride and a monodecanoylglycerol.
Glyceryl monocaprate is a monoglyceride with antimicrobial properties used in cosmetics, pharmaceuticals, and food as an emulsifier. It offers an effective treatment for herpes labialis when combined with low-dose doxycycline. It is not a therapeutic drug but has applications as an antimicrobial agent and cosmetic ingredient. |
| Molecular Formula |
C13H26O4
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|---|---|
| Molecular Weight |
246.35
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| Exact Mass |
246.183
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| CAS # |
26402-22-2
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| PubChem CID |
92926
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| Appearance |
Light yellow to yellow liquid
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| Density |
1.017 g/cm3
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| Melting Point |
53ºC
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| Flash Point |
129.6ºC
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| Vapour Pressure |
5.96E-07mmHg at 25°C
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| Index of Refraction |
1.466
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| LogP |
2.023
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
12
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| Heavy Atom Count |
17
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| Complexity |
182
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(OCC(O)CO)(=O)CCCCCCCCC
|
| InChi Key |
LKUNXBRZDFMZOK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H26O4/c1-2-3-4-5-6-7-8-9-13(16)17-11-12(15)10-14/h12,14-15H,2-11H2,1H3
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| Chemical Name |
2,3-dihydroxypropyl decanoate
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| Synonyms |
Glyceryl caprate; 1-Decanoyl-rac-glycerol; Glyceryl monocaprate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~41.67 mg/mL (~169.16 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.44 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0593 mL | 20.2963 mL | 40.5927 mL | |
| 5 mM | 0.8119 mL | 4.0593 mL | 8.1185 mL | |
| 10 mM | 0.4059 mL | 2.0296 mL | 4.0593 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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