| Size | Price | Stock | Qty |
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| 5mg |
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| Other Sizes |
| Targets |
Glucosinalbate does not have a well-defined pharmacological target as it is a naturally occurring compound. Glucosinolates are plant secondary metabolites that are hydrolyzed by the enzyme myrosinase to produce bioactive compounds such as isothiocyanates, nitriles, and thiocyanates. These hydrolysis products have various biological activities including antimicrobial, anticancer, and anti-inflammatory effects. Glucosinalbate serves as a precursor to bioactive compounds upon enzymatic hydrolysis.
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| ln Vitro |
In vitro, Glucosinalbate is studied as a natural product and glucosinolate. Upon hydrolysis by myrosinase, it releases bioactive isothiocyanates. The compound's activity is typically evaluated in studies of plant metabolism and glucosinolate biology. It is used as a reference standard in analytical assays. Its hydrolysis products have been studied for various biological activities.
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| ln Vivo |
In vivo, Glucosinalbate is studied as part of the glucosinolate-myrosinase system in plants. When plant tissues are damaged, glucosinolates are hydrolyzed to produce bioactive compounds. These compounds have been studied for their effects on herbivores and pathogens. Glucosinalbate's role in plant defense and human nutrition has been investigated.
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| Enzyme Assay |
The cell-free assay for Glucosinalbate involves its detection and quantification in plant extracts. HPLC or LC-MS/MS methods are used to measure glucosinolate levels. The compound serves as a reference standard for method development and validation. Its hydrolysis by myrosinase can be studied in vitro. These assays are used for studying plant metabolism and glucosinolate biology.
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| Cell Assay |
For in vitro cellular assays, Glucosinalbate is typically used as a reference compound. Its hydrolysis products may be tested for biological activities including antimicrobial, anticancer, and anti-inflammatory effects. Cells are treated with hydrolysis products at various concentrations. Cell viability and functional assays are performed. The compound's role as a glucosinolate precursor is studied.
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| Animal Protocol |
In vivo animal studies for Glucosinalbate are limited, as the compound is primarily studied in plants. Its hydrolysis products have been studied in animal models of cancer and inflammation. The compound's role in plant defense against herbivores and pathogens has been investigated. Studies have also explored its potential in human nutrition.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Glucosinalbate include a molecular weight of 423.46 g/mol and molecular formula C15H21NO9S2. As a natural product, its pharmacokinetics are studied in the context of glucosinolate metabolism. The compound is typically stored at appropriate conditions as a research reagent. Detailed ADME parameters are available from studies of glucosinolate metabolism.
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| Toxicity/Toxicokinetics |
The toxicity profile of Glucosinalbate is not well-characterized as it is a naturally occurring compound. Its hydrolysis products have been studied for their safety. The compound is intended for research use only and not for therapeutic applications. Standard safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
Sinalbin has been reported in white mustard seeds, sea cabbage, and other organisms for which data is available.
Glucosinalbate is a natural product isolated from Arabidopsis thaliana and other plants. It is an alkylglucosinolate that serves as a precursor to bioactive isothiocyanates upon enzymatic hydrolysis by myrosinase. Glucosinalbate has been reported in Sinapis alba and Brassica oleracea. It is a research tool for studying plant metabolism, glucosinolate biology, and potential health benefits of glucosinolate hydrolysis products. |
| Molecular Formula |
C14H19NO10S2
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|---|---|
| Molecular Weight |
425.4314
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| Exact Mass |
425.045
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| CAS # |
19253-84-0
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| Related CAS # |
Glucosinalbate potassium;16411-05-5
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| PubChem CID |
415565
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| Appearance |
White to light yellow solid powder
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| Melting Point |
191 - 192 °C
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| LogP |
-0.6
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
27
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| Complexity |
602
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
WWBNBPSEKLOHJU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H19NO10S2/c16-6-9-11(18)12(19)13(20)14(24-9)26-10(15-25-27(21,22)23)5-7-1-3-8(17)4-2-7/h1-4,9,11-14,16-20H,5-6H2,(H,21,22,23)
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| Chemical Name |
[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] 2-(4-hydroxyphenyl)-N-sulfooxyethanimidothioate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3506 mL | 11.7528 mL | 23.5056 mL | |
| 5 mM | 0.4701 mL | 2.3506 mL | 4.7011 mL | |
| 10 mM | 0.2351 mL | 1.1753 mL | 2.3506 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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