| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| 250mg |
|
||
| Other Sizes |
|
| ln Vivo |
In mice fed a high-fat diet, sulforaphane decreases body weight growth and improves energy expenditure. In mice given a high-fat diet, sulforaphane enhances insulin sensitivity and glucose tolerance. Nevertheless, in Nrf2−/− mice, sulforaphane has neither anti-obesity or insulin-sensitizing effects. In wild-type mice's white adipose depots, sulforaphane can prevent the HFD-induced decline in Ucp1 protein levels, but not in Nrf2−/− mice. Sulforaphane can lessen oxidative stress and hepatic steatosis brought on by an HFD. In the liver and adipose tissue, glucoseraphanin prevents HFD-induced pro-inflammatory macrophage activation. Moreover, sulforaphane lowers the proportion of Proteobacteria and LPS in the gut microbiome of mice given a high-fat diet [1]. The shortening of the social avoidance period in stressed mice was dramatically decreased when mice were fed pellets containing 0.1% glucoraphanin (GF). Treatment with pellets containing 0.1% GF significantly reduced the reduction in sucrose preference in stressed mice in the 1% sucrose preference test (SPT) [2].
|
|---|---|
| References |
|
| Additional Infomation |
Glucoraphanin is under investigation in clinical trial NCT01879878 (Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]).
|
| Molecular Formula |
C12H23NO10S3
|
|---|---|
| Molecular Weight |
437.5067
|
| Exact Mass |
436.041
|
| CAS # |
21414-41-5
|
| PubChem CID |
9548634
|
| Appearance |
White to light yellow solid powder
|
| LogP |
-0.53
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
13
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
26
|
| Complexity |
593
|
| Defined Atom Stereocenter Count |
5
|
| SMILES |
CS(=O)CCCC/C(=N\OS(=O)(=O)O)/S[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
|
| InChi Key |
GMMLNKINDDUDCF-RFOBZYEESA-N
|
| InChi Code |
InChI=1S/C12H23NO10S3/c1-25(18)5-3-2-4-8(13-23-26(19,20)21)24-12-11(17)10(16)9(15)7(6-14)22-12/h7,9-12,14-17H,2-6H2,1H3,(H,19,20,21)/b13-8+/t7-,9-,10+,11-,12+,25?/m1/s1
|
| Chemical Name |
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1E)-5-methylsulfinyl-N-sulfooxypentanimidothioate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 76.5 mg/mL (~174.85 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (228.57 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2857 mL | 11.4283 mL | 22.8566 mL | |
| 5 mM | 0.4571 mL | 2.2857 mL | 4.5713 mL | |
| 10 mM | 0.2286 mL | 1.1428 mL | 2.2857 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
