| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
In vitro, ginkgo acid has an IC50 value of 3.0 μM, which inhibits the SUMOylation of RanGAP1-C2. Treatment with ginkgo acid markedly lowered SUMOylated p53 levels. Crucially, ubiquitination of proteins in cells is unaffected by ginkgolic acid. In a dose-dependent way, ginkgo acid prevents E1 from binding to GA-BODIPY [1]. Concentration-dependently, ginkgolic acid (31.2 μg/mL) can inhibit HIV protease activity by 60% when compared to the negative control. Using 50 and 100 μg/mL of ginkgo acid can successfully prevent HIV infection in human peripheral blood monoclonal cells. At concentrations up to 150 μg/mL, ginkgo acid does not significantly harm Jurkat cells [2]. Only in a dose- and time-dependent manner did GA suppress the growth of tumorigenic cell lines. 70.53±4.54% of Hep-2 and 63.5±7.2% of Tca8113 cells were arrested in the GO/G1 phase after being treated with GA for 72 hours. The corresponding apoptosis percentages were 40.4±1.58 and 38.4±1.7%, respectively. The expression of anti-apoptotic Bcl-2 protein is downregulated and pro-apoptotic Bax protein is upregulated when activated caspase-3 is treated with GA. This ultimately results in a decrease in the Bcl-2/Bax ratio of tumor cells in human PBMC cells. At concentrations up to 150 μg/mL, ginkgo acid does not significantly harm Jurkat cells [3].
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| References |
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| Additional Infomation |
Ginkgoic acid is a hydroxybenzoic acid. It is functionally related to a salicylic acid.
Ginkgolic acid has been reported in Myrcia multiflora, Ozoroa insignis, and other organisms with data available. |
| Molecular Formula |
C22H34O3
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|---|---|
| Molecular Weight |
346.51
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| Exact Mass |
346.25
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| CAS # |
22910-60-7
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| Related CAS # |
Ginkgolic Acid (C13:0);20261-38-5
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| PubChem CID |
5281858
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
492.1±40.0 °C at 760 mmHg
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| Melting Point |
136-137ºC
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| Flash Point |
265.5±23.8 °C
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| Vapour Pressure |
0.0±1.3 mmHg at 25°C
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| Index of Refraction |
1.527
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| LogP |
9.44
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
25
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| Complexity |
364
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCC/C=C\CCCCCCCC1=C(C(=CC=C1)O)C(=O)O
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| InChi Key |
YXHVCZZLWZYHSA-FPLPWBNLSA-N
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| InChi Code |
InChI=1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
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| Chemical Name |
2-hydroxy-6-[(Z)-pentadec-8-enyl]benzoic acid
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| Synonyms |
AK46666 AK-46666 Ginkgoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~288.60 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (7.94 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (7.94 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8859 mL | 14.4296 mL | 28.8592 mL | |
| 5 mM | 0.5772 mL | 2.8859 mL | 5.7718 mL | |
| 10 mM | 0.2886 mL | 1.4430 mL | 2.8859 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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