| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
|
||
| 25mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
| ln Vitro |
Although it is highly absorbed and can build up in several human tissues, gamma-tocopherol (D-γ-tocopherol) is mostly converted to 2,7,8-trimethyl-2-(β-carboxyethyl) -6-Hydroxychroman (gamma-CEHC), which is primarily eliminated by urine [1]. The incidence of prostate cancer and cardiovascular disease is inversely correlated with plasma concentrations of γ-tocopherol (D-γ-tocopherol) [1].
|
|---|---|
| References | |
| Additional Infomation |
γ-Tocopherol is a tocopherol in which the 7th and 8th positions of the cromoglycan-6-ol core are replaced by methyl groups. It is primarily found in corn and soybean oil. γ-Tocopherol is a plant metabolite, a food antioxidant, and an algal metabolite. It is a form of vitamin E and a tocopherol. γ-Tocopherol is currently being studied in the clinical trial NCT00836368 (Study on the in vitro basophil response to allergen-induced allergic asthma after γ-tocopherol supplementation in patients). γ-Tocopherol has been reported in perilla, soybeans, and several other organisms with relevant data. γ-Tocopherol is a naturally occurring, fat-soluble form of vitamin E with high oral bioavailability, found in certain nuts and seeds, and possesses potential antioxidant activity. Although the exact mechanism of action of this tocopherol is not fully understood, γ-Tocopherol appears to have the ability to scavenge free radicals, thereby protecting the body from oxidative damage. It is a natural tocopherol, and its antioxidant activity is lower than that of α-Tocopherol. Its antioxidant activity is due to the phenolic hydroxyl hydrogen on its 2H-1-benzopyran-6-ol core. Similar to β-tocopherol, it also contains three methyl groups on its 6-chromanol core, but in different positions.
|
| Molecular Formula |
C₂₈H₄₈O₂
|
|---|---|
| Molecular Weight |
416.68
|
| Exact Mass |
416.365
|
| CAS # |
54-28-4
|
| PubChem CID |
92729
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
0.933g/cm3
|
| Boiling Point |
200 °C (0.1 mmHg)
|
| Melting Point |
-67.50 °C. @ 760.00 mm Hg
|
| Flash Point |
206ºC
|
| Index of Refraction |
n20/D 1.505
|
| LogP |
8.531
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
30
|
| Complexity |
475
|
| Defined Atom Stereocenter Count |
3
|
| SMILES |
O1C2=C(C([H])([H])[H])C(C([H])([H])[H])=C(C([H])=C2C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])O[H]
|
| InChi Key |
QUEDXNHFTDJVIY-DQCZWYHMSA-N
|
| InChi Code |
InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1
|
| Chemical Name |
(2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
|
| Synonyms |
γTocopherol; γ Tocopherol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~239.99 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.00 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (6.00 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3999 mL | 11.9996 mL | 23.9992 mL | |
| 5 mM | 0.4800 mL | 2.3999 mL | 4.7998 mL | |
| 10 mM | 0.2400 mL | 1.2000 mL | 2.3999 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
