| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| 100g |
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| 200g |
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| Other Sizes |
| Targets |
Gamma cyclodextrin interacts with various enzymes, proteins, and other biomolecules. Its mechanism of action involves its interaction with CGTase (cyclodextrin glycosyltransferase), the enzyme that catalyzes the conversion of starch into cyclodextrins, with gamma-cyclodextrin being the predominant product. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex.
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|---|---|
| ln Vitro |
In vitro, gamma cyclodextrin exhibits antiviral activity against SARS-CoV-2 by inhibiting the cytotoxicity of VERO-6 cells. It is used as a carrier, flavor modifier, and stabilizer for foods. Its ability to form inclusion complexes with various molecules makes it a valuable tool for studying molecular interactions.
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| ln Vivo |
In vivo, gamma cyclodextrin is used as a carrier for flavours, sweeteners, colours, vitamins, and polyunsaturated fatty acids. It is permitted for use as an inert ingredient in non-food pesticide products. Its safety and efficacy as a food additive have been evaluated in short-term (28- and 90-day) studies.
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| Enzyme Assay |
In vitro assays for gamma cyclodextrin typically involve studying its ability to form inclusion complexes with various molecules. The formation of complexes can be assessed using techniques such as nuclear magnetic resonance (NMR), X-ray diffraction, and isothermal titration calorimetry (ITC).
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| Cell Assay |
Cell-based assays for gamma cyclodextrin are limited, as the compound is primarily used as a carrier or stabilizer. Its antiviral activity against SARS-CoV-2 has been assessed in VERO-6 cells.
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| Animal Protocol |
In vivo animal studies for gamma cyclodextrin are conducted to assess its safety and efficacy as a food additive and as a carrier for various substances. Short-term (28- and 90-day) studies have been performed in rodents.
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| ADME/Pharmacokinetics |
Gamma cyclodextrin has a molecular weight of 1297.12 and a molecular formula of C48H80O40. It demonstrates solubility in water with a value of 23.2 grams per 100 milliliters. It is not a skin irritant in rabbits and shows no evidence of skin sensitization in guinea pigs.
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| Toxicity/Toxicokinetics |
Gamma cyclodextrin is considered non-toxic and is safe for use in food and pharmaceutical applications. It is not a skin irritant and does not cause sensitization.
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| Additional Infomation |
γ-Cyclodextrin is a cyclic starch composed of eight α-(1->4) linked D-pyranose units.
Gamma cyclodextrin (γ-CD) is a cyclic oligosaccharide composed of eight glucose units. It is used as a carrier, flavor modifier, and stabilizer for foods. It is also an impurity of sugammadex. Its ability to form inclusion complexes makes it a valuable tool for studying molecular interactions and for pharmaceutical formulations. |
| Molecular Formula |
C48H80O40
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|---|---|
| Molecular Weight |
1297.12
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| Exact Mass |
1296.422
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| CAS # |
17465-86-0
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| Related CAS # |
93959-99-0
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| PubChem CID |
5287407
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| Appearance |
White to off-white solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
845.2°C (rough estimate)
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| Melting Point |
267ºC
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| Flash Point |
450℃
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| Index of Refraction |
1.591
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| LogP |
-8.97
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| Hydrogen Bond Donor Count |
24
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| Hydrogen Bond Acceptor Count |
40
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| Rotatable Bond Count |
8
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| Heavy Atom Count |
88
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| Complexity |
1720
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| Defined Atom Stereocenter Count |
40
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| SMILES |
C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CO)CO)CO)CO)CO)CO)CO)O)O)O
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| InChi Key |
GDSRMADSINPKSL-HSEONFRVSA-N
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| InChi Code |
InChI=1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1
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| Chemical Name |
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36S,38R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
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| Synonyms |
gamma-Dextrin Cyclooctaamylose Gamma cyclodextrin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~77.09 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (1.93 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (1.93 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (1.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.7709 mL | 3.8547 mL | 7.7094 mL | |
| 5 mM | 0.1542 mL | 0.7709 mL | 1.5419 mL | |
| 10 mM | 0.0771 mL | 0.3855 mL | 0.7709 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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