| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
γ-L-glutamyl-L-alanine (γ-Glu-Ala) has an EC50 of 4.8 µM and demonstrates Ca2+i mobilization potency in HEK-293 cells expressing CaR (calcium-sensing receptor)[3]. In human parathyroid cells, γ-L-glutamyl-L-alanine exhibits potency in Ca2+i mobilization, with an EC50 of 13.9 µM [3]. Normal human parathyroid cells' secretion of PTH is inhibited by γ-L-glutamyl-L-alanine (20 μM) [3]. A substrate of glutaminase B is γ-L-glutamyl-L-alanine [4].
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|---|---|
| References | |
| Additional Infomation |
Gamma-Glu-Ala is a gamma-glutamylalanine obtained by formal condensation of the gamma-carboxy group of L-glutamic acid with the amino group of L-alanine. It has a role as a Saccharomyces cerevisiae metabolite and a plant metabolite. It is a conjugate acid of a gamma-Glu-Ala(1-).
gamma-Glutamylalanine has been reported in Homo sapiens, Dietes iridioides, and other organisms with data available. gamma-Glutamylalanine has been reported in Homo sapiens, Dietes iridioides, and other organisms with data available. L-gamma-Glutamyl-L-alanine is a metabolite found in or produced by Saccharomyces cerevisiae. |
| Molecular Formula |
C8H14N2O5
|
|---|---|
| Molecular Weight |
218.21
|
| Exact Mass |
218.09
|
| CAS # |
5875-41-2
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| PubChem CID |
440103
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| Appearance |
White to off-white solid powder
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| Density |
1.362g/cm3
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| Boiling Point |
564.4ºC at 760mmHg
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| Melting Point |
188-192ºC(lit.)
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| Flash Point |
295.1ºC
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| Index of Refraction |
1.527
|
| LogP |
-3.8
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
15
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| Complexity |
266
|
| Defined Atom Stereocenter Count |
2
|
| SMILES |
C[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N
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| InChi Key |
WQXXXVRAFAKQJM-WHFBIAKZSA-N
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| InChi Code |
InChI=1S/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1
|
| Chemical Name |
(2S)-2-amino-5-[[(1S)-1-carboxyethyl]amino]-5-oxopentanoic acid
|
| Synonyms |
gamma-Glutamyl-L-alanine; G-Glu-Ala; G-Glu-Ala
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~229.14 mM)
DMSO : ~1 mg/mL (~4.58 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (458.27 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.5827 mL | 22.9137 mL | 45.8274 mL | |
| 5 mM | 0.9165 mL | 4.5827 mL | 9.1655 mL | |
| 10 mM | 0.4583 mL | 2.2914 mL | 4.5827 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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