| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Furprofen targets cyclooxygenase (COX) enzymes, inhibiting prostaglandin synthesis. This reduces the production of prostaglandins, which are key mediators of pain, inflammation, and fever. Its mechanism of action is similar to that of other propionic acid derivatives like ibuprofen.
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|---|---|
| ln Vitro |
In vitro, Furprofen inhibits prostaglandin synthesis. Its activity is similar to other NSAIDs, such as ibuprofen and ketoprofen, which it is structurally related to.
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| ln Vivo |
In vivo, Furprofen acts as an analgesic and anti-inflammatory agent. Its mechanism of action involves the inhibition of prostaglandin synthesis, which reduces pain and inflammation.
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| Enzyme Assay |
In vitro non-cell enzyme assays for Furprofen typically involve measuring the inhibition of COX-1 and COX-2 activity using purified enzymes or microsomal preparations and arachidonic acid as a substrate. Prostaglandin production is measured by ELISA or radiometric methods. IC₅₀ values are calculated.
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| Cell Assay |
In vitro cell-based assays for Furprofen use inflammatory cells, such as macrophages, stimulated with LPS. Cells are treated with the compound, and the production of prostaglandin E₂ (PGE₂) is measured by ELISA to assess its anti-inflammatory activity.
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| Animal Protocol |
In vivo animal studies for Furprofen employ standard models of pain and inflammation, such as the carrageenan-induced paw edema test or the acetic acid-induced writhing test. The compound is administered orally, and its ability to reduce inflammation or pain is assessed.
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| ADME/Pharmacokinetics |
Furprofen has a molecular weight of 244.24 g/mol and a molecular formula of C₁₄H₁₂O₄. It is soluble in ethanol (100 mg/mL) and DMSO (62.5 mg/mL). It should be stored at -20°C. As a small molecule, it is expected to be orally bioavailable.
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| Toxicity/Toxicokinetics |
The toxicity profile of Furprofen is expected to be similar to other NSAIDs, including gastrointestinal irritation, renal effects, and cardiovascular risks at high doses. Comprehensive toxicological data are limited as it is a research compound.
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| References |
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| Additional Infomation |
Furprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, structurally related to ibuprofen and ketoprofen. It acts by inhibiting prostaglandin synthesis. It is a research compound used to study pain and inflammation. Not approved for clinical use.
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| Molecular Formula |
C14H12O4
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|---|---|
| Molecular Weight |
244.24268
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| Exact Mass |
244.074
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| CAS # |
66318-17-0
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| PubChem CID |
162201
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| Appearance |
Light yellow to yellow ointment
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| Density |
1.252g/cm3
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| Boiling Point |
425.5ºC at 760 mmHg
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| Flash Point |
211.1ºC
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| Index of Refraction |
1.571
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| LogP |
2.698
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
18
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| Complexity |
318
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC(C1=CC=C(C=C1)C(=O)C2=CC=CO2)C(=O)O
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| InChi Key |
ITJUVDBADHDNPU-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H12O4/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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| Chemical Name |
2-[4-(furan-2-carbonyl)phenyl]propanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol : ~100 mg/mL (~409.43 mM)
DMSO : ~62.5 mg/mL (~255.90 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.17 mg/mL (8.88 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.17 mg/mL (8.88 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 21.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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