| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg | |||
| Other Sizes |
| Targets |
Fungichromin targets fungal pathogens by binding to ergosterol in cell membranes, disrupting their integrity. This interaction with membrane sterols is its primary mechanism of action.
|
|---|---|
| ln Vitro |
Streptomyces sp. produces largosin. The antifungal activity of the Dabaishan pine endophyte WP-1 against Fusarium oxysporum [1].
In vitro, Fungichromin demonstrates potent and broad-spectrum antifungal activity against a range of pathogenic fungi, including Rhizoctonia solani, Fusarium oxysporum, and Candida albicans. It inhibits fungal cell growth and spore germination. It is also reported to have antitumor activity. |
| ln Vivo |
In vivo activity data for Fungichromin is not detailed in the available literature. As an antifungal agent, its in vivo efficacy would be evaluated in animal models of fungal infections, but specific studies are not cited.
|
| Enzyme Assay |
The antifungal activity of Fungichromin is assessed using standard antimicrobial susceptibility tests, such as broth microdilution or agar diffusion assays. These methods measure the compound's ability to inhibit the growth of various fungal strains.
|
| Cell Assay |
Fungichromin's mechanism of action is studied in cell-based assays. Its binding to ergosterol in fungal cell membranes and its effects on membrane integrity are key areas of investigation.
|
| Animal Protocol |
Specific in vivo animal models are not detailed. Given its antifungal activity, relevant models would include systemic or topical infection models in mice or other animals to assess its efficacy in treating fungal infections.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for Fungichromin is not available in the provided literature. As a polyene macrolide, its properties would be typical of this class of antibiotics, but specific data is not provided.
|
| Toxicity/Toxicokinetics |
Specific toxicity data is not available. Polyene macrolides, like amphotericin B, are known for their nephrotoxicity. The safety profile of Fungichromin would be a critical factor in its development, but specific data is not provided.
|
| References | |
| Additional Infomation |
Fungichromin are macrolide antibiotics with antifungal activity. It has been reported that pentoxyverine exists in Streptomyces cellulosae, and relevant data are available for reference.
Fungichromin is a research compound with potent antifungal and antitumor activities. Its broad-spectrum activity and reported lack of drug resistance make it a valuable candidate for studying fungal physiology and developing new antifungal agents. |
| Molecular Formula |
C35H58O12
|
|---|---|
| Molecular Weight |
670.82782
|
| Exact Mass |
670.393
|
| Elemental Analysis |
C, 62.67; H, 8.72; O, 28.62
|
| CAS # |
6834-98-6
|
| Related CAS # |
6834-98-6;
|
| PubChem CID |
5282200
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.196g/cm3
|
| Boiling Point |
914ºC at 760 mmHg
|
| Flash Point |
278.4ºC
|
| Index of Refraction |
1.545
|
| LogP |
0.858
|
| Hydrogen Bond Donor Count |
10
|
| Hydrogen Bond Acceptor Count |
12
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
47
|
| Complexity |
1020
|
| Defined Atom Stereocenter Count |
12
|
| SMILES |
CCCCCC(C1C(CC(CC(CC(CC(CC(C(C(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O)O
|
| InChi Key |
AGJUUQSLGVCRQA-SWOUQTJZSA-N
|
| InChi Code |
InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14+/t23-,24+,25-,26+,27-,28+,29-,30+,31-,32-,33-,34-/m1/s1
|
| Chemical Name |
(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
|
| Synonyms |
Fungichromin; Cogomycin; Lagosin; Pentamycin; S 232; S-232; S232; Pentamycin
|
| HS Tariff Code |
2934.99.03.00
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~74.53 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (3.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4907 mL | 7.4535 mL | 14.9069 mL | |
| 5 mM | 0.2981 mL | 1.4907 mL | 2.9814 mL | |
| 10 mM | 0.1491 mL | 0.7453 mL | 1.4907 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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