| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 100mg |
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| 250mg |
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Fucosterol is a natural product isolated from E. stolonifera with antioxidant, antidiabetic, and anti-inflammatory, anti-adipogenic, and anti-cancer activities. Regulates adipogenesis via modulation of PPARαand C/EBPα expression.
| ln Vitro |
In comparison to fully differentiated control adipocytes, fumasterol (0-50 μM; 7 days) inhibits the expression of C/EBPα and PPARα [1]. With IC50 values of 27.94 and 70.41 μg/ml, respectively, fumonisin is cytotoxic to T47D and HT29 cell lines[3]. With IC50 values of 185.4, 43.3, and 34.0 μg/ml, respectively, fumonisin inhibits the proliferation of HEK293, MCF-7, and SiHa cells [4].
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| ln Vivo |
Oral treatment of 30 mg/kg of fumosterol significantly lowers serum glucose levels and prevents the build-up of sorbitol in the lens [2].
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| Cell Assay |
Cell viability assay [1]
Cell Types: 3T3-L1 adipocyte Tested Concentrations: 0 μM; 25 μM; 50 μM Incubation Duration: 7 days Experimental Results: Inhibition of PPARα and C/EBPα expression. |
| References |
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| Additional Infomation |
Isofucosterol is a 3beta-sterol consisting of stigmastan-3beta-ol with double bonds at positions 5 and 24(28). The double bond at postion 24(28) adopts a Z-configuration. It has a role as an animal metabolite, a plant metabolite, an algal metabolite and a marine metabolite. It is a 3beta-sterol, a 3beta-hydroxy-Delta(5)-steroid, a C29-steroid and a member of phytosterols. It derives from a hydride of a stigmastane.
Fucosterol has been reported in Equisetum arvense, Solanum tuberosum, and other organisms with data available. See also: Fucosterol (annotation moved to). |
| Molecular Formula |
C29H48O
|
|---|---|
| Molecular Weight |
412.702
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| Exact Mass |
412.371
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| CAS # |
17605-67-3
|
| PubChem CID |
5281326
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| Appearance |
White to off-white solid powder
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| Density |
0.98 g/cm3
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| Boiling Point |
504.2ºC at 760 mmHg
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| Melting Point |
118-120ºC
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| Flash Point |
220.3ºC
|
| Vapour Pressure |
2.8E-12mmHg at 25°C
|
| Index of Refraction |
1.53
|
| LogP |
7.944
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
30
|
| Complexity |
687
|
| Defined Atom Stereocenter Count |
8
|
| SMILES |
C/C=C(/CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)\C(C)C
|
| InChi Key |
OSELKOCHBMDKEJ-WGMIZEQOSA-N
|
| InChi Code |
InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h7,10,19-20,23-27,30H,8-9,11-18H2,1-6H3/b21-7-/t20-,23+,24+,25-,26+,27+,28+,29-/m1/s1
|
| Chemical Name |
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(Z,2R)-5-propan-2-ylhept-5-en-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
|
| Synonyms |
28-Isofucosterol Fucosterol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol : ~16.67 mg/mL (~40.39 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (4.05 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear EtOH + stock solution to 900 μL of corn oil and mix well. Solubility in Formulation 2: 10 mg/mL (24.23 mM) in Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; Need ultrasonic and warming and heat to 45°C. View More
Solubility in Formulation 3: 6.25 mg/mL (15.14 mM) in 17% Polyethylene glycol 12-hydroxystearate in Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; Need ultrasonic and warming and heat to 42°C. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4231 mL | 12.1153 mL | 24.2307 mL | |
| 5 mM | 0.4846 mL | 2.4231 mL | 4.8461 mL | |
| 10 mM | 0.2423 mL | 1.2115 mL | 2.4231 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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