| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
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| ln Vitro |
In DDT1 MF2 cells, FSCPX has an IC50 of 11.8±3.2 nM, which is an irreversible block of [3H]-8-cyclopentyl-1,3dipropylxanthine ([3H]DPCPX; 1]. When applied to A1AR-overexpressing LLC-PK1 cells, FSCPX (20 μM; 48 hours) reduces their resistance to necrosis and apoptosis [3]. A1AR-overexpressing LLC-PK1 cells that have their HSP27 mRNA and protein overexpressed reversed when treated with FSCPX (2–20 μM) after 48 hours [3]. HSP70 mRNA and protein unaffected.
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|---|---|
| References |
[1]. Beauglehole AR, et, al. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21): 3179-82.
[2]. Erdei T, et, al. FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. Molecules. 2018 Aug 3 [3]. Lee HT, et, al. Renal tubule necrosis and apoptosis modulation by A1 adenosine receptor expression. Kidney Int. 2007 Jun;71(12):1249-61. |
| Molecular Formula |
C23H27N4O6FS
|
|---|---|
| Molecular Weight |
506.54708
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| Exact Mass |
506.164
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| CAS # |
156547-56-7
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| PubChem CID |
133012
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| Appearance |
Solid powder
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| Vapour Pressure |
3.28E-21mmHg at 25°C
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| LogP |
3.94
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
10
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| Heavy Atom Count |
35
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| Complexity |
898
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCN1C(=O)N(CCCOC(C2C=CC(S(F)(=O)=O)=CC=2)=O)C2N=C(NC=2C1=O)C1CCCC1
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| InChi Key |
XJLGXHIRSHTRPQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H27FN4O6S/c1-2-12-28-21(29)18-20(26-19(25-18)15-6-3-4-7-15)27(23(28)31)13-5-14-34-22(30)16-8-10-17(11-9-16)35(24,32)33/h8-11,15H,2-7,12-14H2,1H3,(H,25,26)
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| Chemical Name |
3-(8-cyclopentyl-2,6-dioxo-1-propyl-7H-purin-3-yl)propyl 4-fluorosulfonylbenzoate
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~98.71 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.94 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9741 mL | 9.8707 mL | 19.7414 mL | |
| 5 mM | 0.3948 mL | 1.9741 mL | 3.9483 mL | |
| 10 mM | 0.1974 mL | 0.9871 mL | 1.9741 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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