| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
When combined with mitogens, frentizole (500 ng/mL, 48 h) potently inhibits the incorporation of thymidine into DNA in lymphocyte cultures. It also strongly inhibits lymphocytes that are retrieved from the peritoneal cavity of mice in a way that is dependent on dose. In cells, 58% of the cells responded to concanavalin A [1]. The effective suppression of uridine incorporation by fermizole (62.5 ng/mL) is not reliant on the specific phytochemical employed [1].
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| ln Vivo |
For a period of 52 weeks, lentizole (8.2 or 79.9 mg/kg/day) can prolong the lives of NZB/NZW mice [2].
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| Animal Protocol |
Animal/Disease Models: NZB/NZW mice [2]
Doses: Young mice 8.2 or 79.9 mg/kg/day Route of Administration: In animal breeding; 52 weeks Experimental Results: demonstrated that the average life span of untreated young mice was 38 weeks, The low-dose group lived an average of about 38 weeks, and the high-dose group lived Dramatically longer, with an average lifespan of about 61 weeks. The white blood cell counts were Dramatically suppressed compared with the average peripheral blood leukocyte count of 4160 in control mice, 3217 in low-dose treated mice, and 3450 in high-dose treated mice. Terminal neutrophil counts were Dramatically increased in young mice treated with both low and high doses compared with controls. |
| References |
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| Molecular Formula |
C15H13N3O2S
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|---|---|
| Molecular Weight |
299.348
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| Exact Mass |
299.073
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| CAS # |
26130-02-9
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| PubChem CID |
33334
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| Appearance |
White to off-white solid powder
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| Density |
1.42g/cm3
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| Index of Refraction |
1.752
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| LogP |
4.035
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
21
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| Complexity |
363
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
JHBWYQRKOUBPCA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H13N3O2S/c1-20-11-7-8-12-13(9-11)21-15(17-12)18-14(19)16-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
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| Chemical Name |
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea
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| Synonyms |
LY-53616; LY53616; LY 53616
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~12.5 mg/mL (~41.76 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 1.25 mg/mL (4.18 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 1.25 mg/mL (4.18 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3406 mL | 16.7029 mL | 33.4057 mL | |
| 5 mM | 0.6681 mL | 3.3406 mL | 6.6811 mL | |
| 10 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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