| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
Fosminomycin sodium salt is an antibiotic that is phosphonate-based[1][2], effective against both Gram-positive and Gram-negative bacteria[3].
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|---|---|
| ln Vivo |
It appeared that animals given intraperitoneal doses of fosminomycin exceeding 10 mg/kg were free of parasites. Following 5 mg/kg fosminomycin treatment, the parasitemia was less than 1%. When 20 mg/kg of oral fosminomycin was administered, the parasitemia was less than 1%, and the animals treated with the antibiotic were significantly free of parasites. Relapse was noted upon stopping treatment after four days. After eight days of receiving 30 mg/kg fosminomycin, mice were totally cured [3].
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| References |
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| Additional Infomation |
Fosmidomycin sodium salt is a phosphonoacetic acid.
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| Molecular Formula |
C4H9NNAO5P
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|---|---|
| Molecular Weight |
205.0815
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| Exact Mass |
205.011
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| CAS # |
66508-37-0
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| Related CAS # |
66508-37-0 (sodium); 66508-53-0 (free);
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| PubChem CID |
5141362
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| Appearance |
White to light brown solid powder
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| Boiling Point |
463.7ºC at 760 mmHg
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| Melting Point |
189-191ºC
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| Flash Point |
234.3ºC
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| LogP |
0.347
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
12
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| Complexity |
177
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ZZPUYRHMTGOTEU-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C4H10NO5P.Na/c6-4-5(7)2-1-3-11(8,9)10;/h4,7H,1-3H2,(H2,8,9,10);/q;+1/p-1
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| Chemical Name |
sodium;3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate
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| Synonyms |
FR 31564; FR-31564; Fosmidomycin sodium
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~25 mg/mL (~121.90 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (487.61 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8761 mL | 24.3807 mL | 48.7615 mL | |
| 5 mM | 0.9752 mL | 4.8761 mL | 9.7523 mL | |
| 10 mM | 0.4876 mL | 2.4381 mL | 4.8761 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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