| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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Purity: ≥98%
Fondaparinux sodium (PENTA; SR-90107A; IC-85158; Arixtra; Xantidar) is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII).
| ln Vitro |
The first novel anticoagulant that targets factor Xa specifically is fondaparinux sodium. The IC50 value (anti-Xa IU/ml) for fondaparinux is 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for MMPs (monocyte-derived microparticles) [2].
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|---|---|
| ln Vivo |
The pharmacokinetics of fondaparinux sodium are linear and dose-dependent, resulting in a very predictable response. With a quick start of action, a half-life of 14 to 16 hours, and continuous antithrombotic activity for 24 hours, fondaparinux sodium is 100% bioavailable. The medication has no effect on platelet function or aggregation, prothrombin time, or activated partial thromboplastin time [1].
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| References |
[1]. Bauer KA. et al. Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S14-7.
[2]. Ben-Hadj-Khalifa S, et al. Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation. Blood Coagul Fibrinolysis. 2011 Jul;22(5):369-73. |
| Molecular Formula |
C31H43N3NA10O49S8
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|---|---|
| Molecular Weight |
1728.0815
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| CAS # |
114870-03-0
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| Related CAS # |
104993-28-4;114870-03-0 (sodium);
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| SMILES |
S(N([H])[C@@]1([H])[C@@]([H])(O[C@]2([H])[C@]([H])(C(=O)[O-])O[C@]([H])([C@@]([H])([C@@]2([H])O[H])OS(=O)(=O)[O-])O[C@]2([H])[C@@]([H])(C([H])([H])OS(=O)(=O)[O-])O[C@@]([H])([C@@]([H])([C@@]2([H])O[H])N([H])S(=O)(=O)[O-])OC([H])([H])[H])O[C@]([H])(C([H])([H])OS(=O)(=O)[O-])[C@]([H])([C@]1([H])OS(=O)(=O)[O-])O[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C(=O)[O-])O1)O[C@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])OS(=O)(=O)[O-])O1)O[H])O[H])N([H])S(=O)(=O)[O-])O[H])O[H])(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~125 mg/mL (~72.33 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (57.87 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.5787 mL | 2.8934 mL | 5.7868 mL | |
| 5 mM | 0.1157 mL | 0.5787 mL | 1.1574 mL | |
| 10 mM | 0.0579 mL | 0.2893 mL | 0.5787 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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