| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| 500mg | |||
| Other Sizes |
| Targets |
Flupyrimin targets the insect nicotinic acetylcholine receptor (nAChR). It acts as an antagonist at the insect nAChR. By blocking the nAChR, the compound disrupts neurotransmission in the insect nervous system, leading to insecticidal effects. It exhibits broad-spectrum insecticidal activity.
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|---|---|
| ln Vitro |
In vitro, Flupyrimin exhibits broad-spectrum insecticidal activity. It acts as an antagonist at the insect nicotinic acetylcholine receptor (nAChR). It is less toxic to pollinators (100 µg/bee).
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| ln Vivo |
In vivo, Flupyrimin is an insecticidal compound used to control pests in agricultural settings. It is less toxic to rats (2000 mg/kg). It is used as an insecticide.
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| Enzyme Assay |
The in vitro receptor binding assay for Flupyrimin involves measuring its binding affinity to the insect nicotinic acetylcholine receptor (nAChR). This is typically done using radiolabeled ligand competition assays on insect cell membranes expressing nAChRs. The compound's antagonist activity is assessed by measuring its ability to block nAChR-mediated responses.
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| Cell Assay |
In vitro cell-based assays for Flupyrimin involve treating insect cell lines or neurons with the compound and measuring nAChR activity using electrophysiology or calcium imaging. The compound's effects on insect cell viability are also assessed.
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| Animal Protocol |
In vivo animal studies for Flupyrimin involve administering the compound to insects (e.g., pests) and assessing mortality. The compound's efficacy in controlling pest populations is evaluated in agricultural settings. Toxicity to non-target organisms, such as pollinators and rats, is also assessed.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Flupyrimin are not extensively detailed in the available literature. The compound is an insecticide. For storage, it should be kept at 2-10°C.
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| Toxicity/Toxicokinetics |
No specific toxicity data for Flupyrimin are available in the provided literature. It is less toxic to pollinators (100 µg/bee) and rats (2000 mg/kg). The compound is for research use only.
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| References | |
| Additional Infomation |
Flupyrimin is an insecticidal compound that targets the insect nicotinic acetylcholine receptor. It exhibits broad-spectrum insecticidal activity. It is developed by Meiji Seika Pharma. Its CAS number is 1689566-03-7.
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| Molecular Formula |
C13H9CLF3N3O
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|---|---|
| Molecular Weight |
315.678272008896
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| Exact Mass |
315.038
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| CAS # |
1689566-03-7
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| PubChem CID |
14127920
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
3
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
21
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| Complexity |
488
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1=CC=C(C=N1)CN1C=CC=C/C/1=N\C(C(F)(F)F)=O
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| InChi Key |
DHQKLWKZSFCKTA-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C13H9ClF3N3O/c14-10-5-4-9(7-18-10)8-20-6-2-1-3-11(20)19-12(21)13(15,16)17/h1-7H,8H2
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| Chemical Name |
N-[1-[(6-chloropyridin-3-yl)methyl]pyridin-2-ylidene]-2,2,2-trifluoroacetamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~250 mg/mL (~791.94 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.59 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.59 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (6.59 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1678 mL | 15.8388 mL | 31.6776 mL | |
| 5 mM | 0.6336 mL | 3.1678 mL | 6.3355 mL | |
| 10 mM | 0.3168 mL | 1.5839 mL | 3.1678 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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