| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vivo |
Urine from rats and dogs given 14C-Flumexadol (CERM1841) contained 14C. Compared to rats, dog feces had a noticeably greater 14C removal rate. In both species, conjugated metabolites, primarily glucuronides, were responsible for the majority of urine radioactivity. These two species' biotransformation products are mostly acids, with a small number of alkaline metabolites and a few neutral compounds coming in second and third, respectively. Three-trifluoromethylhippuric acid and three-trifluoromethylbenzoic acid are the main urine metabolites in rats. In dogs, 3-trifluoromethylmandelic acid is present in addition to benzoic acid and its conjugates. The medication that remained intact and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, of which the former was predominant, were the basic components found in the urine of both species [3].
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|---|---|
| References |
| Molecular Formula |
C11H12NOF3
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|---|---|
| Molecular Weight |
231.21428
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| Exact Mass |
231.087
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| CAS # |
30914-89-7
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| PubChem CID |
65774
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.209g/cm3
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| Boiling Point |
271.5ºC at 760mmHg
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| Flash Point |
118ºC
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| Index of Refraction |
1.464
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| LogP |
2.695
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
16
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| Complexity |
232
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC(=CC(=C1)C(F)(F)F)C2CNCCO2
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| InChi Key |
GXPYCYWPUGKQIJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H12F3NO/c12-11(13,14)9-3-1-2-8(6-9)10-7-15-4-5-16-10/h1-3,6,10,15H,4-5,7H2
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| Chemical Name |
2-[3-(trifluoromethyl)phenyl]morpholine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~144.15 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.81 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.81 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (10.81 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3251 mL | 21.6254 mL | 43.2507 mL | |
| 5 mM | 0.8650 mL | 4.3251 mL | 8.6501 mL | |
| 10 mM | 0.4325 mL | 2.1625 mL | 4.3251 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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