| Size | Price | Stock | Qty |
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| 100mg |
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| 500mg |
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Fipexide (Attentil, Vigilor) is a psychoactive drug of the piperazine class. It is a parachloro-phenossiacetic acid derivative acting as a nootropic agent. It was developed in Italy in 1983. It was used in Italy and France for the treatment of senile dementia but is no longer in common use due to undesirable side effects including fever and hepatitis.
| ln Vitro |
In Arabidopsis wild-type seedlings, fipexide (50 μM) exhibits a simple structure with areas of active division and epidermal sections with fully expanded cells [2].
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| ln Vivo |
Fipexide (10 mg/kg; oral; 5–10 days) totally removes convulsion-related memory impairments[3].
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| Animal Protocol |
Animal/Disease Models: Ignite rats[3]
Doses: 10 mg/kg Route of Administration: oral; 5-10 Day Experimental Results:Complete elimination of memory defects caused by ignition. Antagonizes the amnestic effects of pentylenetetrazol (PTZ) ignition. |
| References |
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| Additional Infomation |
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone is a member of benzodioxoles.
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| Molecular Formula |
C20H21N2O4CL.HCL
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|---|---|
| Molecular Weight |
425.30568
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| Exact Mass |
388.119
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| CAS # |
34161-24-5
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| Related CAS # |
Fipexide hydrochloride;34161-23-4
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| PubChem CID |
3351
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| Appearance |
White to off-white solid powder
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| Density |
1.342g/cm3
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| Boiling Point |
559.3ºC at 760mmHg
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| Flash Point |
292.1ºC
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| LogP |
2.667
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
27
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| Complexity |
492
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BFUJHVVEMMWLHC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H21ClN2O4/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18/h1-6,11H,7-10,12-14H2
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| Chemical Name |
1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~321.47 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.35 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.08 mg/mL (5.35 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3512 mL | 11.7561 mL | 23.5123 mL | |
| 5 mM | 0.4702 mL | 2.3512 mL | 4.7025 mL | |
| 10 mM | 0.2351 mL | 1.1756 mL | 2.3512 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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