| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 500mg | |||
| Other Sizes |
| ln Vitro |
In MARC-145 cells, the Filipin complex (2 μg/mL; 1+48 hours) decreases PRRSV entrance and 61% of the virus's genome replication in infected cells is reduced [2].
|
|---|---|
| References | |
| Additional Infomation |
Filipin III is a macrolide compound and the main component of a mixture of four isomeric polyene macrolide compounds isolated from Streptomyces filipinensis. It is both a bacterial metabolite and a fluorescent probe. It is a macrolide compound, as well as a polyol and olefin compound. Filipin has been reported to exist in Streptomyces miharaensis, Streptomyces avermitilis, and other organisms with relevant data. Filipin III is a polyene antibiotic complex obtained from Streptomyces filipinensis. It alters membrane function by interfering with membrane sterols, inhibiting mitochondrial respiration, and is considered an antifungal agent. Filipin I, II, and IV have relatively weaker effects.
|
| Molecular Formula |
C35H58O11
|
|---|---|
| Molecular Weight |
654.82842
|
| Exact Mass |
654.398
|
| CAS # |
11078-21-0
|
| PubChem CID |
6433194
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.161 g/cm3
|
| Boiling Point |
913.9ºC at 760 mmHg
|
| Flash Point |
279.3ºC
|
| LogP |
1.888
|
| Hydrogen Bond Donor Count |
9
|
| Hydrogen Bond Acceptor Count |
11
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
46
|
| Complexity |
991
|
| Defined Atom Stereocenter Count |
11
|
| SMILES |
CCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O
|
| InChi Key |
IMQSIXYSKPIGPD-YQRUMEKGSA-N
|
| InChi Code |
InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
|
| Chemical Name |
(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL
Ethanol : ~10 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5271 mL | 7.6356 mL | 15.2711 mL | |
| 5 mM | 0.3054 mL | 1.5271 mL | 3.0542 mL | |
| 10 mM | 0.1527 mL | 0.7636 mL | 1.5271 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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