Size | Price | Stock | Qty |
---|---|---|---|
1mg |
|
||
5mg |
|
||
25mg |
|
||
50mg |
|
||
100mg |
|
||
250mg |
|
||
Other Sizes |
|
Purity: ≥98%
Description:FGI-106 HCl is a novel, highly potent and broad-spectrum antiviral agent with inhibitory activity against multiple viruses. FGI-106 tetraHCl is active against various viruses such as Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetraHCl also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
Targets |
HIV-1
|
---|---|
ln Vitro |
Applying 2 μM FGI-106 resulted in a 4 log decrease in infectious viral titers in comparison to matched controls. The estimated EC90 for inhibiting viral killing of host cells (Vero E6 cells) was 0.6 μM.
Treatment with FGI-106 inhibits the replication of various virus families, such as positive- and negative-strand RNA viruses, in cell-based assays[1]. |
ln Vivo |
Zaire EBOV mortality is reduced in a dose-dependent manner by FGI-106 (0.1–5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment[1].
|
Animal Protocol |
Animal Model: The Ebola virus (EBOV) is injected into male or female C57BL/6 or BALB/c mice (6–10 weeks of age)[1].
Dosage: 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg Administration: Intraperitoneal injection; treatments on days 2 and 5 Result: Decreased mortality from Zaire EBOV in a dose-dependent manner. |
References |
Molecular Formula |
C28H42CL4N6
|
---|---|
Molecular Weight |
604.49
|
Exact Mass |
458.32
|
Elemental Analysis |
C, 55.64; H, 7.00; Cl, 23.46; N, 13.90
|
CAS # |
1149348-10-6
|
Related CAS # |
FGI-106;501081-38-5
|
Appearance |
Solid powder
|
SMILES |
CC1=CC(NCCCN(C)C)=C2C=CC3=C4N=C(C)C=C(NCCCN(C)C)C4=CC=C3C2=N1.Cl.Cl.Cl.Cl
|
InChi Key |
YUQCVPFHAFZFPV-UHFFFAOYSA-N
|
InChi Code |
InChI=1S/C28H38N6.4ClH/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6;;;;/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32);4*1H
|
Chemical Name |
N1,N7-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine tetrahydrochloride
|
Synonyms |
FGI-106; FGI106; FGI 106; FGI-106 HCl; FGI-106 hydrochloride; FGI-106 tetrahydrochloride;
|
HS Tariff Code |
2934.99.9001
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO : ~6.67 mg/mL (~11.03 mM)
|
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.67 mg/mL (1.11 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 6.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.67 mg/mL (1.11 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 6.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6543 mL | 8.2714 mL | 16.5429 mL | |
5 mM | 0.3309 mL | 1.6543 mL | 3.3086 mL | |
10 mM | 0.1654 mL | 0.8271 mL | 1.6543 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.