| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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| ln Vitro |
The IC50 values of ferroquine against non-cancerous MRC-5 and HeLa cancer cells are 24.4 µM and 16.8 µM, respectively, indicating its cytotoxicity[1]. When exposed to 33.3 µM diferroquin after a 24-hour incubation period, all newly transformed Schistosoma worms (NTS) showed a substantial reduction in vitality [1].
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| ln Vivo |
Ferroquine dosages of 200 and 800 mg/kg decreased the overall worm burden in mice by 19.4% and 35.6%, respectively. Within 24 hours of receiving 800 mg/kg of ferroquine, one of the mice was dead. When mice were given 200 mg/kg RQ, no action was seen. Finally, following FQ-OH treatment, a drop of 17.3% in the overall worm burden was noted. Consequently, adding ferrocenyl or ruthenenyl fragments to chloroquine (CQ) does not make it more effective against schistosomiasis. By contrast, a greater reduction in parasite burden of 72.3% was obtained in S with 200 mg/kg mefloquine (MQ). mice afflicted with Mansoni. greater effects on adult female S. mansoni were also seen in mice given MQ, indicating that these medications interfere with the target in a way that is particular to a given sex. Furthermore, liver metastasis—the migration of worms to the liver—was seen in one FQ-OH-treated animal, along with a large number of dead worms. As a result, in vivo antischistosomiasis activity is weak for ferroquine and FQ-OH [1].
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| References |
[1]. Keiser J, et al. In vitro and in vivo antischistosomal activity of ferroquine derivatives. Parasit Vectors. 2014 Sep 4;7:424
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| Molecular Formula |
C23H24CLFEN3
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|---|---|
| Molecular Weight |
433.76
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| Exact Mass |
433.1
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| CAS # |
185055-67-8
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| PubChem CID |
140118553
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| Appearance |
Light yellow to orange solid powder
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| LogP |
4.729
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
28
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| Complexity |
419
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1=CC=C2C(NC[C-]34[Fe+2]56789%10%11([CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12)C3(CN(C)C)=[CH]5[CH]6=[CH]47)=CC=NC2=C1
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| InChi Key |
DDENDDKMBDTHAX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2
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| Chemical Name |
7-chloro-N-[[2-[(dimethylamino)methyl]cyclopenta-2,4-dien-1-yl]methyl]quinolin-4-amine;cyclopenta-1,3-diene;iron(2+)
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| Synonyms |
SR97193; SSR-97193; SR-97193
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~4.35 mg/mL (~10.03 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (1.91 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3054 mL | 11.5271 mL | 23.0542 mL | |
| 5 mM | 0.4611 mL | 2.3054 mL | 4.6108 mL | |
| 10 mM | 0.2305 mL | 1.1527 mL | 2.3054 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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