| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
Purity: ≥98%
| Targets |
Fenpropidin's mechanism of action involves inhibition of ergosterol biosynthesis in fungi, a pathway essential for fungal cell membrane integrity and function. By inhibiting sterol biosynthesis, fenpropidin disrupts fungal cell membrane formation, leading to growth inhibition and cell death. It is active against powdery mildews of grain and other fungal pathogens.
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| ln Vitro |
Fenpropidin demonstrates fungicidal activity against various fungal pathogens, particularly powdery mildews of grain. Its in vitro activity can be assessed using agar diffusion or broth microdilution methods against target fungal species. The compound's effectiveness is measured by determining the minimum inhibitory concentration (MIC) required to inhibit fungal growth.
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| ln Vivo |
Fenpropidin is used in vivo as a fungicide in agricultural applications to control fungal diseases in crops such as grapes, apples, and pears. It is particularly effective against powdery mildews of grain. The compound is applied as a spray or other formulation to protect crops from fungal infection.
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| Enzyme Assay |
Non-cellular enzyme assays for fenpropidin involve assessing its inhibition of enzymes in the ergosterol biosynthesis pathway, such as sterol C14-reductase or sterol C8-isomerase. The enzyme activity is measured using radiolabeled substrates or by HPLC analysis of sterol intermediates. IC50 values for enzyme inhibition are determined from dose-response curves.
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| Cell Assay |
In vitro cellular assays for fenpropidin involve treating fungal cultures (e.g., powdery mildew pathogens) with the compound and assessing growth inhibition. Cultures are incubated with varying concentrations of fenpropidin, and fungal growth is measured by colony diameter, biomass accumulation, or spectrophotometric methods. MIC values are determined from dose-response curves.
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| Animal Protocol |
In vivo animal experiments are not applicable for fenpropidin as it is an agricultural fungicide rather than a therapeutic compound. Efficacy studies are conducted in plant models rather than animals. Plants infected with fungal pathogens are treated with fenpropidin, and disease severity is assessed. The compound's protective and curative activities are evaluated in field trials or greenhouse studies.
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| ADME/Pharmacokinetics |
Fenpropidin has a molecular weight of 273.46 and a molecular formula of C19H31N. It is a pale yellow, viscous, odorless liquid with a boiling point >250°C and a relative density of 0.91 at 20°C. The compound has a logP (octanol/water) of 2.9 at pH 7 and a Henry's constant of 10.7 Pa·m³/mol at 25°C. It is soluble in chloroform and ethyl acetate and is typically stored at -20°C.
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| Toxicity/Toxicokinetics |
Fenpropidin is generally considered to have low toxicity to mammals at recommended application rates. Standard safety precautions should be followed when handling the compound, as it may cause skin, eye, and respiratory irritation. The compound should be used with caution to avoid exposure to non-target organisms.
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| References | |
| Additional Infomation |
1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine belongs to the piperidine class of compounds. Its structure is similar to N-isobutylpiperidine, except that one of the hydrogen atoms on the methyl group is replaced by a p-tert-butylphenyl group. It is both a piperidine compound and a tertiary amine. Fenpridine has been studied for the treatment of hernias.
Fenpropidin (CAS 67306-00-7) is a synthetic piperidine fungicide used in agriculture to control fungal diseases, particularly powdery mildews of grain. It inhibits ergosterol biosynthesis in fungi. The compound is applied as a spray to protect crops such as grapes, apples, and pears from fungal infection. Fenpropidin is available from various commercial suppliers for research and agricultural applications. |
| Molecular Formula |
C19H31N
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|---|---|
| Molecular Weight |
273.46
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| Exact Mass |
273.246
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| CAS # |
67306-00-7
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| PubChem CID |
91694
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.924 g/cm3
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| Boiling Point |
368.9ºC at 760 mmHg
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| Melting Point |
25°C
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| Flash Point |
159.3ºC
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| Index of Refraction |
1.507
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| LogP |
4.586
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
20
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| Complexity |
264
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1CCN(CC(CC2C=CC(C(C)(C)C)=CC=2)C)CC1
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| InChi Key |
MGNFYQILYYYUBS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H31N/c1-16(15-20-12-6-5-7-13-20)14-17-8-10-18(11-9-17)19(2,3)4/h8-11,16H,5-7,12-15H2,1-4H3
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| Chemical Name |
1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
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| Synonyms |
Ro-12-3049; Ro 12-3049; Fenpropidin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~365.68 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (9.14 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.14 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.14 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6568 mL | 18.2842 mL | 36.5684 mL | |
| 5 mM | 0.7314 mL | 3.6568 mL | 7.3137 mL | |
| 10 mM | 0.3657 mL | 1.8284 mL | 3.6568 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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