| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Following i.v. injection in rats, over 90% of the /Fast Green FCF/ was excreted in the bile within 4 hours. Dogs were given orally 200 mg of the /Fast Green FCF/... a bile fistula was made for bile analysis. ... The amount of /Fast Green FCF found in the bile/ never exceeded 5% of the given dose. ... Rats ... were given orally 200 mg of the /Fast Green FCF/... the urine and feces were collected for 36 hours. ... Almost all the administered /Fast Green FCF/ was excreted unchanged in the feces of rats. No /Fast Green FCF/ was found in the urine. ... |
|---|---|
| Toxicity/Toxicokinetics |
Interactions
... When a combination of half the concentrations of Indigo carmine (secondary amine containing dye), Fast green FCF (tertiary amine containing dye) and nitrite was given, the values of SCEs were consistently lower than the sum of the expected values of the agents given individually. This indicates antagonistic response between the dyes and nitrite on SCEs. Non-Human Toxicity Values LD50 Dog oral > 200 mg/dog LD50 Rat oral > 2,000 mg/kg bw |
| References | |
| Additional Infomation |
Fast green FCF is an organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellowish in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent. It has a role as a histological dye, a fluorochrome and a food colouring. It contains a Fast green FCF(2-).
|
| Molecular Formula |
C37H36N2NA2O10S3
|
|---|---|
| Molecular Weight |
810.85
|
| Exact Mass |
808.117
|
| CAS # |
2353-45-9
|
| Related CAS # |
2353-45-9 (sodium);25738-40-3 (free acid);
|
| PubChem CID |
16887
|
| Appearance |
Dark green to black solid powder
|
| Melting Point |
290ºC
|
| LogP |
7.974
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
11
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
54
|
| Complexity |
1540
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
RZSYLLSAWYUBPE-UHFFFAOYSA-L
|
| InChi Code |
InChI=1S/C37H36N2O10S3.2Na/c1-3-38(24-26-7-5-9-33(21-26)50(41,42)43)30-15-11-28(12-16-30)37(35-20-19-32(40)23-36(35)52(47,48)49)29-13-17-31(18-14-29)39(4-2)25-27-8-6-10-34(22-27)51(44,45)46;;/h5-23H,3-4,24-25H2,1-2H3,(H3,41,42,43,44,45,46,47,48,49);;/q;2*+1/p-2
|
| Chemical Name |
disodium;2-[[4-[ethyl-[(3-sulfonatophenyl)methyl]amino]phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]-5-hydroxybenzenesulfonate
|
| Synonyms |
Fast Green FCF CCRIS 1867 C.I. Food Green 3, disodium salt NSC-379443 NSC379443 NSC 379443
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~10 mg/mL (~12.36 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 4.55 mg/mL (5.63 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.2333 mL | 6.1664 mL | 12.3327 mL | |
| 5 mM | 0.2467 mL | 1.2333 mL | 2.4665 mL | |
| 10 mM | 0.1233 mL | 0.6166 mL | 1.2333 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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