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1mg |
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5mg |
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10mg |
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Other Sizes |
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Falcarindiol is a polyyne olyacetylenic oxylipin with anti-inflammatory, antifungal, anticancer and antidiabetic activities. It activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells.
ln Vitro |
The cell viability of MDA-MB-231 and MDA-MB-468 cells was significantly reduced by falcarindiol (3, 6, 12, 24 μM) over a 24-hour period. The cell viability of MCF-10A cells was maintained until the dose of Falcarindiol reached 24 μM, at which point Falcarindiol preferentially induced breast cancer cell death [1]. In MDA-MB-231, MDA-MB-468, and SKBR3 cells, falcarindiol (6 μM; for 2 hours) induces autophagy and leads to significant levels of LC3-I. Falcarindiol (6 μM; for 2, 4, 8, and 24 hours) dose- and time-supplementedly increases GRP78 levels in MDA-MB-231 cells [1]. Falcarindiol (1–20 μM) has no effect on the viability of HT-29 and hMSC cells. Cells can only be toxically affected by concentrations of falcarindiol greater than 50 μM [2]. Over the course of 24 hours, falcarindiol (5 μM; 10 minutes, 1 hour, and 24 hours) dramatically increases PPARγ2 expression [2].
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ln Vivo |
The expression of ABCA1 is upregulated in tumor tissues when falcarindiol (7 μg/g; food) is introduced at five weeks of age [2].
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References |
[1]. Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12(4):e0176348.
[2]. Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524. |
Molecular Formula |
C17H24O2
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Molecular Weight |
260.37126
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CAS # |
55297-87-5
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Related CAS # |
(+)-(3R,8S)-Falcarindiol;225110-25-8
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SMILES |
CCCCCCC/C=C\[C@@H](C#CC#C[C@H](C=C)O)O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 33.33 mg/mL (~128.01 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 1.11 mg/mL (4.26 mM) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 11.1 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.8407 mL | 19.2034 mL | 38.4069 mL | |
5 mM | 0.7681 mL | 3.8407 mL | 7.6814 mL | |
10 mM | 0.3841 mL | 1.9203 mL | 3.8407 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.