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    Ezatiostat
    Ezatiostat

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3435
    CAS #: 168682-53-9Purity ≥98%

    Description: Ezatiostat (formerly known as TER199; TLK199; Brand name: Telentra) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1). It was shown that an ezatiostat response profile contains two miRNAs that regulate expression of genes known to be implicated in MDS disease pathology. Remarkably, pathway analysis of the response profile revealed that the genes comprising the jun-N-terminal kinase/c-Jun molecular pathway, which is known to be activated by ezatiostat, are under-expressed in patients who respond and over-expressed in patients who were non-responders to the drug, suggesting that both the biology of the disease and the molecular mechanism of action of the drug are positively correlated.

    References:  2012 May 6;5:20. 

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    EzatiostatName: Ezatiostat
    CAS#: 168682-53-9 (free base)
    Chemical Formula: C27H35N3O6S
    Exact Mass: 529.22466
    Molecular Weight: 529.6483
    Elemental Analysis: C, 61.23; H, 6.66; N, 7.93; O, 18.12; S, 6.05
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: TLK199; TLK-199; TLK 199; Ezatiostat; TER-199; TLK-199 hydrochloride; TER 199; TLK 199 hydrochloride; TER199; TLK199 hydrochloride; trade name: Telintra
    Chemical Name: (S)-ethyl 2-amino-5-(((R)-3-(benzylthio)-1-(((S)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate
    InChi Key: GWEJFLVSOGNLSS-FIXSFTCYSA-N
    InChi Code: InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24-/m0/s1
    SMILES Code: O=C(OCC)[[email protected]@H](N)CCC(N[[email protected]@H](CSCC1=CC=CC=C1)C(N[[email protected]@H](C2=CC=CC=C2)C(OCC)=O)=O)=O


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    Ezatiostat


    Patients who responded to ezatiostat under-expressed miR-129 (A) and over-expressed miR-155 (B).  2012 May 6;5:20.

     Ezatiostat


    Three pathways, mTOR, JAK2, and JNK, were under-expressed in patients who responded to ezatiostat.  2012 May 6;5:20.



    These protocols are for reference only. InvivoChem does not independently validate these methods.

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