| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Etofenprox acts on voltage-gated sodium channels by inhibiting channel inactivation and prolonging channel opening. This disrupts the normal transmission of action potentials in the insect nervous system, leading to paralysis and death. It is classified as an IRAC Mode of Action group 3A insecticide.
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| ln Vitro |
The half-lethal dose (LD50) of ethofen is 23 ng/bird, and it has an inductive effect on domestic frequencies [1].
In vitro, etofenprox has been shown to modulate voltage-gated sodium channels. Its insecticidal activity is assessed in bioassays using target insect species, where the compound is applied topically or orally, and mortality is recorded. Cross-resistance studies have shown that mechanisms such as carboxylesterase, elevated esterase, and GST do not affect etofenprox toxicity. |
| ln Vivo |
Etofenate axetil (powder: 0.25, 0.5, and 1%; daily cardiovascular, for 8 days) is shown to have a positive effect on F344-weight severe tumors, suggesting that it activates CAR ligation and increases the generation of microsomal ROS, which in turn upregulates the Nrf2 gene [ 2].
Etofenprox is used in vivo as an insecticide in agriculture, veterinary care, and public health pest control. It is toxic to many pests, including Diptera, and is effective against a broad spectrum of insects. It is used to control weevils, beetles, aphids, moths, whiteflies, thrips, borers, fleas, and mosquitoes. |
| Enzyme Assay |
Non-cellular assays for etofenprox are limited, as it is an ion channel modulator. Its effects on voltage-gated sodium channels can be assessed using electrophysiological techniques with isolated membrane patches or cells expressing the channels. Its physicochemical properties can be characterized using standard analytical techniques.
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| Cell Assay |
In vitro cellular assays for etofenprox involve treating insect neuronal cultures or cells expressing voltage-gated sodium channels with the compound and measuring its effects on channel function using patch-clamp electrophysiology. The compound's effects on channel inactivation and opening are assessed. Its cytotoxicity can be evaluated in insect cell lines.
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| Animal Protocol |
In vivo animal experiments with etofenprox are conducted in insect pest species to assess its efficacy. Target insects are exposed to etofenprox-treated surfaces or diets, and mortality is monitored. Toxicological studies are conducted in mammals to assess the compound's safety for agricultural workers and consumers.
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| ADME/Pharmacokinetics |
Etofenprox has a molecular weight of 376.49 and a molecular formula of C₂₅H₂₈O₃. It is a solid at room temperature with a purity of ≥98%. The compound is typically stored at room temperature in a dry, dark place. It is soluble in organic solvents and is stable under recommended storage conditions.
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| Toxicity/Toxicokinetics |
Etofenprox is generally considered to have low toxicity to mammals, but it can be toxic to fish and aquatic organisms. It may cause skin and eye irritation. Standard safety precautions should be followed when handling the compound. It should be kept away from heat and open flames.
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| References |
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| Additional Infomation |
Etofenprox is an aromatic ether, specifically the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylprop-1-ol. It is a pyrethroid insecticide. Its structure is similar to that of 2-(4-ethoxyphenyl)-2-methylprop-1-ol.
Etofenprox (CAS 80844-07-1) is a non-ester pyrethroid insecticide that acts on voltage-gated sodium channels. It is a contact-kill adulticide used to control a wide variety of insect pests. It is classified as an IRAC Group 3A insecticide and is used in agriculture, veterinary medicine, and public health. |
| Molecular Formula |
C25H28O3
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|---|---|
| Molecular Weight |
376.4880
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| Exact Mass |
376.203
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| CAS # |
80844-07-1
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| PubChem CID |
71245
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| Appearance |
Off-white to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
481.6±40.0 °C at 760 mmHg
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| Melting Point |
36ºC
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| Flash Point |
165.1±24.6 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.559
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| LogP |
7.34
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
9
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| Heavy Atom Count |
28
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| Complexity |
422
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C1C=C(COCC(C)(C)C2C=CC(OCC)=CC=2)C=CC=1)C1C=CC=CC=1
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| InChi Key |
YREQHYQNNWYQCJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3
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| Chemical Name |
1-ethoxy-4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]benzene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~265.61 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.64 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (6.64 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.64 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6561 mL | 13.2806 mL | 26.5611 mL | |
| 5 mM | 0.5312 mL | 2.6561 mL | 5.3122 mL | |
| 10 mM | 0.2656 mL | 1.3281 mL | 2.6561 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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