| Size | Price | Stock | Qty |
|---|---|---|---|
| 50g |
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| Other Sizes |
| Targets |
Ethyl maltol targets taste and olfactory receptors as a flavoring agent. As an odor-active compound, it interacts with olfactory receptors to produce its characteristic sweet caramel-like aroma. The compound is a pyranone that functions as a flavor enhancer in food and beverage products. Its mechanism of action involves binding to taste and olfactory receptors to elicit sweet and fruity flavor perceptions. Ethyl maltol is commonly used as a flavoring agent in chocolate, candy, juice, bread, pastries, alcoholic beverages, soft drinks, and dairy products.
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| ln Vitro |
In vitro, Ethyl maltol demonstrates odor-active properties as a food additive. It is a common flavorant in confectioneries and other food products. The compound has a sweet caramel-like odor and a sweet, fruity taste. It is soluble in chloroform and methanol and has a logP (o/w) of 0.61. Ethyl maltol has a melting point of 88-92°C and a boiling point of 289-290°C. Its flavoring properties have been characterized in sensory evaluation studies.
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| ln Vivo |
In vivo, Ethyl maltol is used as a flavoring agent in foods and beverages. It is generally recognized as safe and is added to many commercial e-cigarette vaping fluids and has been detected in the aerosols. The compound is widely used in food flavor formulations as a flavor enhancer and flavor corrector, commonly used in chocolate, candy, juice, bread, pastries, alcoholic beverages, soft drinks, cold drinks, and dairy products. It is also used in tobacco flavor formulations.
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| Enzyme Assay |
Ethyl maltol sensory evaluation assays involve assessing its odor and taste properties. The compound's odor is described as sweet, burnt cotton sugar candy-like with jammy and strawberry notes. Taste is described as sweet and fruity. For analytical applications, Ethyl maltol is detected and quantified by HPLC, GC, or other analytical methods. Assays are performed with appropriate sensory panels or analytical standards. The compound's logP (0.61) and pKa (8.38) are determined through physicochemical characterization.
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| Cell Assay |
Ethyl maltol cell-based assays are limited as the compound is primarily a flavoring agent rather than a therapeutic compound. Cell viability and toxicity studies may be performed to assess safety. Cells are cultured in appropriate media and treated with Ethyl maltol at varying concentrations. Cell viability is assessed by standard assays. The compound's generally recognized as safe status is based on extensive safety evaluation. Experiments are performed with appropriate controls.
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| Animal Protocol |
Ethyl maltol in vivo studies are conducted in animal models for safety evaluation. The compound is generally recognized as safe for use in food products. Toxicological studies have been performed to establish safety profiles. The compound is metabolized and excreted following ingestion. For flavoring studies, animal models may be used to assess taste preference or aversion. Animals are monitored for clinical signs. Tissues and blood samples are collected for biochemical analysis at study endpoints. Studies are conducted in accordance with institutional animal care guidelines.
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| ADME/Pharmacokinetics |
Ethyl maltol (MW 140.14 g/mol, C7H8O3) is a small pyranone compound. It appears as a white to light yellow crystalline powder. The compound is soluble in water, alcohol, propylene glycol, and chloroform. It has a melting point of 88-92°C and a boiling point of 289-290°C. The logP (o/w) is 0.61 and the pKa is 8.38. Ethyl maltol is generally recognized as safe as a food additive.
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| Toxicity/Toxicokinetics |
Ethyl maltol is generally recognized as safe for use as a food additive. It is hazardous in case of skin contact (irritant), eye contact (irritant), ingestion, and inhalation. Standard safety precautions should be followed when handling the compound. No significant adverse effects have been reported at research-use concentrations. The compound is intended for research use only. Comprehensive toxicological evaluation is available from food safety studies.
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| Additional Infomation |
Ethyl maltol is a pyranone compound. It has been reported that mangoes (Mangifera indica) contain ethyl maltol, and relevant data are available for reference.
Ethyl maltol is an odor-active compound and important food additive that gives food aroma. It has a sweet caramel-like odor and sweet, fruity taste. Ethyl maltol is commonly used as a flavoring agent in chocolate, candy, juice, bread, pastries, alcoholic beverages, soft drinks, dairy products, and tobacco flavor formulations. It is generally recognized as safe and is added to e-cigarette vaping fluids. Its molecular formula is C7H8O3 with a molecular weight of 140.14 g/mol. All applications are limited to non-human research use. |
| Molecular Formula |
C7H8O3
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|---|---|
| Molecular Weight |
140.1366
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| Exact Mass |
140.047
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| CAS # |
4940-11-8
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| Related CAS # |
Ethyl maltol-d5
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| PubChem CID |
21059
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| Appearance |
White to off-white solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
290.3±40.0 °C at 760 mmHg
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| Melting Point |
85-95 °C(lit.)
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| Flash Point |
124.8±20.8 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.541
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| LogP |
0.61
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
10
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| Complexity |
213
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O1C([H])=C([H])C(C(=C1C([H])([H])C([H])([H])[H])O[H])=O
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| InChi Key |
YIKYNHJUKRTCJL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C7H8O3/c1-2-6-7(9)5(8)3-4-10-6/h3-4,9H,2H2,1H3
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| Chemical Name |
2-ethyl-3-hydroxypyran-4-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~713.57 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (14.84 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.1357 mL | 35.6786 mL | 71.3572 mL | |
| 5 mM | 1.4271 mL | 7.1357 mL | 14.2714 mL | |
| 10 mM | 0.7136 mL | 3.5679 mL | 7.1357 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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