| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
| Targets |
Ethyl docosahexaenoate does not have a traditional therapeutic target. As the ethyl ester of DHA, it is a source of the omega-3 fatty acid DHA. DHA is an essential fatty acid that is incorporated into cell membranes, particularly in the brain and retina, and plays a role in various physiological processes.
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|---|---|
| ln Vitro |
Immobilized lipase can be used to selectively alcoholyse ethyl esters generated from tuna oil and lauryl alcohol, therefore enriching cis-4,7,10,13,16, and 19-docosahexaenoic acid ethyl ester (also known as ethyl docosahexaenoate, or E-DHA) [1].
Ethyl docosahexaenoate is not a therapeutic agent with pharmacological in vitro activity. It is a fatty acid ester used as a source of DHA in research and nutritional applications. |
| ln Vivo |
In vivo, ethyl docosahexaenoate is metabolized to release DHA, which is an essential omega-3 fatty acid. DHA is important for brain development, cognitive function, and cardiovascular health. It is used as a dietary supplement and in nutritional research.
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| Enzyme Assay |
Ethyl docosahexaenoate is not used in cell-free enzyme/receptor binding assays as a test compound. It is a fatty acid ester used as a source of DHA.
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| Cell Assay |
Ethyl docosahexaenoate is not used in cell-based pharmacological assays as a test compound. It is a fatty acid ester used as a source of DHA in cell culture studies.
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| Animal Protocol |
In vivo, ethyl docosahexaenoate is used in nutritional studies to assess the effects of DHA supplementation. It can be administered orally to animal models or humans. Endpoints include DHA levels in tissues, cognitive function, and cardiovascular parameters.
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| ADME/Pharmacokinetics |
Ethyl docosa-4,7,10,13,16,19-hexaenoate (CAS 84494-72-4) has a molecular formula of C24H36O2 and a molecular weight of 356.54 g/mol. It is also known as ethyl cis-4,7,10,13,16,19-docosahexaenoate and DHA ethyl ester. Appearance: typically a liquid. Solubility: insoluble in water, soluble in organic solvents. Storage: typical for fatty acid esters (cool, dark place, protected from oxygen). Purity: typically >97% for research use.
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| Toxicity/Toxicokinetics |
No toxicity data is publicly available. As the ethyl ester of DHA, an essential fatty acid, it is generally considered safe at nutritional doses.
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| References |
[1]. Yuji Shimada, et al. Purification of ethyl docosahexaenoate by selective alcoholysis of fatty acid ethyl esters with immobilized Rhizomucor miehei lipase. J Am Oil Chem Soc. 1998 Nov, 75(11): 1565–1571.
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| Additional Infomation |
Ethyl hexaenoic acid ester (C22-4,7,10,13,16,19-hexaenoic acid) is a polyunsaturated fatty acid ester.
Ethyl docosahexaenoate is a research-grade compound and is not a drug. It is used as a source of DHA in nutritional research and as a dietary supplement. No clinical trials have been reported for this specific compound, but DHA itself has been extensively studied. |
| Molecular Formula |
C24H36O2
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|---|---|
| Molecular Weight |
356.54144
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| Exact Mass |
356.271
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| CAS # |
84494-72-4
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| PubChem CID |
6381521
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| Appearance |
Typically exists as solid at room temperature
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
443.5±24.0 °C at 760 mmHg
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| Flash Point |
102.1±21.2 °C
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| Vapour Pressure |
0.0±1.1 mmHg at 25°C
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| Index of Refraction |
1.504
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| LogP |
7.77
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
16
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| Heavy Atom Count |
26
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| Complexity |
490
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(CCC=CCC=CCC=CCC=CCC=CCC=CCC)OCC
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| InChi Key |
ITNKVODZACVXDS-YATCGRJWSA-N
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| InChi Code |
InChI=1S/C24H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26-4-2/h5-6,8-9,11-12,14-15,17-18,20-21H,3-4,7,10,13,16,19,22-23H2,1-2H3/b6-5+,9-8+,12-11+,15-14+,18-17+,21-20+
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| Chemical Name |
ethyl (4E,7E,10E,13E,16E,19E)-docosa-4,7,10,13,16,19-hexaenoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~280.47 mM)
DMSO : ~100 mg/mL (~280.47 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.01 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.01 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8047 mL | 14.0237 mL | 28.0473 mL | |
| 5 mM | 0.5609 mL | 2.8047 mL | 5.6095 mL | |
| 10 mM | 0.2805 mL | 1.4024 mL | 2.8047 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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