| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
Acridine has a MIC range of 100-200 μg/mL and is effective against Staphylococcus aureus, including MRSA. The MIC of Acridine against E. Proteus vulgaris and Proteus mirabilis have MICs more than 1,600 μg/mL, whereas coli is 200–800 μg/mL[3].
|
|---|---|
| ln Vivo |
Pregnancy can be ended with ethacridine lactate [1].
|
| References |
[1]. Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4(2):59-61.
[2]. Rotin LE, et al. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453. [3]. Usuki R, et, al. Antibacterial Activity of Acrinol against Organisms Isolated from Clinical Materials and Influence of Light on Antibacterial Activity of Acrinol. Japanese Journal of Pharmaceutical Health Care and Sciences. 2004 Jan; 30(2):72-77. |
| Additional Infomation |
Acrinol is an organic molecular entity.
A topically applied anti-infective agent. |
| Molecular Formula |
C18H21N3O4
|
|---|---|
| Molecular Weight |
343.38
|
| Exact Mass |
343.153
|
| CAS # |
1837-57-6
|
| Related CAS # |
Ethacridine lactate monohydrate;6402-23-9
|
| PubChem CID |
15789
|
| Appearance |
Typically exists as solid at room temperature
|
| Boiling Point |
270 °C(lit.)
|
| Melting Point |
62-67 °C(lit.)
|
| Flash Point |
143 °C
|
| Vapour Pressure |
4.72E-11mmHg at 25°C
|
| LogP |
3.565
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
25
|
| Complexity |
371
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(O)C(O)=O.NC1=CC2=NC3=CC=C(OCC)C=C3C(N)=C2C=C1
|
| InChi Key |
IYLLULUTZPKQBW-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-131-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18)2,4H,1H3,(H,5,6)
|
| Chemical Name |
Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1
|
| Synonyms |
NSC-36333 NSC36333NSC 36333
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~145.61 mM)
H2O : ~12.5 mg/mL (~36.40 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.28 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.28 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.28 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9122 mL | 14.5611 mL | 29.1223 mL | |
| 5 mM | 0.5824 mL | 2.9122 mL | 5.8245 mL | |
| 10 mM | 0.2912 mL | 1.4561 mL | 2.9122 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT06487117 | NOT YET RECRUITING | Drug: Huafu Shengji Ointment Drug: ethacridine lactate solution |
Diabetic Foot | Beijing Daxing District Hospital of Integrated Chinese and Western Medicine | 2024-09 | Early Phase 1 |
| NCT03574935 | UNKNOWN STATUS | Drug: External Chinese medicine Drug: External Western medicine |
Diabetic Foot Ulcer, Skin |
Shanghai Yueyang Integrated Medicine Hospital | 2018-07-01 | Phase 2 |
|
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