| Size | Price | Stock | Qty |
|---|---|---|---|
| 25mg |
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| 50mg |
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| 100mg |
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| 250mg | |||
| 500mg | |||
| Other Sizes |
| References |
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| Additional Infomation |
Ergothioneine is an L-histidine derivative, chemically named Nα,Nα,Nα-trimethyl-L-histidine, in which the hydrogen at the 2-position of the imidazole ring is replaced by a thiol group. It is a natural metabolite of histidine, synthesized by bacteria and fungi, and possesses antioxidant properties. Ergothioneine is widely found in animals and plants, and also in many human foods. It has multiple functions, including as an antioxidant, fungal metabolite, plant metabolite, exogenous substance metabolite, and chelating agent. It is an amino acid betaine, belonging to the L-histidine derivative and sulfur-containing amino acid family. It is the conjugate base of ergothioneine (1+). It is the tautomer of the ergothioneine thione form. Ergothioneine has been reported in Drosophila melanogaster, Aster tataricus, and other organisms with relevant data. It is a natural metabolite of histidine with antioxidant properties.
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| Molecular Formula |
C9H15N3O2S
|
|---|---|
| Molecular Weight |
229.29
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| Exact Mass |
229.088
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| CAS # |
497-30-3
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| PubChem CID |
5351619
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| Appearance |
White to off-white solid powder
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| Melting Point |
275-277ºC (dec.)
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| LogP |
-3.43
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
15
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| Complexity |
314
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-]
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| InChi Key |
SSISHJJTAXXQAX-ZETCQYMHSA-N
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| InChi Code |
InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1
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| Chemical Name |
(2S)-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-(trimethylazaniumyl)propanoate
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| Synonyms |
NSC 7175; L-Ergothioneine; Ergothioneine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~125 mg/mL (~545.14 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (436.11 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.3613 mL | 21.8064 mL | 43.6129 mL | |
| 5 mM | 0.8723 mL | 4.3613 mL | 8.7226 mL | |
| 10 mM | 0.4361 mL | 2.1806 mL | 4.3613 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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