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    InvivoChem Cat #: V1745
    CAS #: 531-95-3Purity ≥98%

    Description: Equol [(-)-Equol, (3S)-Equol, (S)-Equol, AUS 131] is an isoflavandiol estrogen metabolized from daidzein, specifically, it is produced by intestinal bacteria in response to soy isoflavone intake in human. Equol is a metabolite of soybeans and is an important isoflavone that shows a wide range of activities including antioxidant activity, anti-inflammation activity and anticancer activity. It is reported that Equol specifically binds to 5α-DHT and has a modest affinity for recombinant estrogen receptor ERβ, which may be responsible for most of Equol's biological properties.  

    References: Bioorg Med Chem. 2004 Mar 15;12(6):1559-67; Eur J Cancer. 1997 Dec;33(14):2384-9.

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    Molecular Weight (MW)242.27 
    CAS No.531-95-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 48 mg/mL (198.1 mM) 
    Water: <1 mg/mL
    Ethanol: 48 mg/mL (198.1 mM) 
    Chemical Name(3S)-3-(4-(3S)-Isoflavan-4,7′-diol; Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol
    Synonyms(-)-(S)-Equol, (-)-Equol, (3S)-Equol, (S)-Equol, AUS 131, Equol, S-Equol, SE 5OH

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    In Vitro

    In vitro activity: Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a Ki of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a Ki of 50 nM. Equol is superior to all other isoflavones in its antioxidant activity. Equol has antioestrogenic properties. Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with 3 H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression.

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    Cell Assay: 

    In VivoEach well of a 24-well plate is seeded with 1 × 105 MCF-7 cells in 1 mL of media B. Twenty-four hours after plating, equol at the indicated concentration is added. Equol is dissolved in ethanol (final concentration of ethanol in the medium is 1%). The medium is changed every 24 hours and equol is replenished with each change. Cell growth is determined on the sixth day by the sulphorhodamine colorimetric assay. After colour development, aliquots are pipetted into a 96-well microtitre plate and the absorbance is determined at 570 nm using an Elisa microplate reader. 
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    Bioorg Med Chem. 2004 Mar 15;12(6):1559-67; Eur J Cancer. 1997 Dec;33(14):2384-9. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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