| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| Targets |
Epirosmanol's mechanism of action is thought to involve the inhibition of pro-inflammatory cytokines and protection of cells from oxidative damage. It shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. As a natural product, it may interact with various cellular targets involved in inflammation, oxidative stress, and cancer cell proliferation.
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| ln Vitro |
In vitro, Epirosmanol shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. It has potential anti-inflammatory and antioxidant effects. Specific in vitro data such as IC50 values and mechanism studies are limited in publicly available sources.
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| ln Vivo |
In vivo studies with Epirosmanol are limited. As a natural compound with anti-inflammatory and antioxidant properties, it has potential therapeutic applications. However, specific in vivo efficacy data are not extensively documented. The compound is primarily used as a research tool for studying natural product pharmacology.
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| Enzyme Assay |
In vitro assays for Epirosmanol include anti-cancer activity assays in melanoma cell lines. Cells are treated with the compound at various concentrations, and cell viability, proliferation, and melanin production are assessed. Anti-inflammatory activity is assessed by measuring cytokine production in immune cells.
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| Cell Assay |
Cell-based assays for Epirosmanol are conducted in melanoma cells and other cancer cell lines. Cells are treated with the compound, and cell viability, apoptosis, and melanin biosynthesis are assessed. Anti-inflammatory effects are assessed in macrophages or other immune cells.
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| Animal Protocol |
In vivo animal experiments with Epirosmanol are limited. The compound could potentially be used in models of cancer, inflammation, or oxidative stress. Specific protocols are not extensively documented.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Epirosmanol have not been extensively characterized. The compound has molecular weight 346.42 and molecular formula C20H26O5. Solubility: DMSO 100 mg/mL (288.67 mM). Storage: powder at -20°C for 2 years; in solvent at -80°C for 1 year. Specific PK parameters have not been reported.
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| Toxicity/Toxicokinetics |
Safety and toxicology data for Epirosmanol are limited. As a natural compound, it may have low toxicity, but comprehensive studies have not been conducted. The compound is for research use only and is not approved for human therapeutic use. Standard laboratory safety precautions should be followed when handling the compound.
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| References |
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| Additional Infomation |
(1R,8R,9S,10S)-3,4,8-trihydroxy-11,11-dimethyl-5-propyl-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-2,4,6-trien-15-one has been reported in Salvia officinalis, other Salvia species, and other organisms for which relevant data exist.
See also: Epirosmanol (note moved to). Epirosmanol has CAS number 93380-12-2, molecular formula C20H26O5, and molecular weight 346.42. It is a natural diterpene lactone found in various organisms. It shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. It has anti-inflammatory and antioxidant effects. Purity: ≥98%. Not for human use; for research purposes only. |
| Molecular Formula |
C20H26O5
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|---|---|
| Molecular Weight |
346.42
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| Exact Mass |
346.178
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| CAS # |
93380-12-2
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| PubChem CID |
23243694
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| Appearance |
White to off-white solid
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| Boiling Point |
574.2±50.0 °C at 760 mmHg
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| LogP |
3.257
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
25
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| Complexity |
572
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O=C1O[C@H]2[C@@H]3[C@]1(CCCC3(C)C)C1C(O)=C(O)C(C(C)C)=CC=1[C@H]2O
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| InChi Key |
LCAZOMIGFDQMNC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H26O5/c1-9(2)10-8-11-12(15(23)13(10)21)20-7-5-6-19(3,4)17(20)16(14(11)22)25-18(20)24/h8-9,14,16-17,21-23H,5-7H2,1-4H3
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| Chemical Name |
3,4,8-trihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~288.67 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8867 mL | 14.4333 mL | 28.8667 mL | |
| 5 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL | |
| 10 mM | 0.2887 mL | 1.4433 mL | 2.8867 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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