| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| Other Sizes |
|
| ln Vivo |
Tumor growth was markedly inhibited by Enpp-1-IN-14 (Compound 015) (50 mg/kg; IP; BID for 31 days) [1].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: Female C57BL/6 mice (4-6 weeks; 2 × 105 MC38 cells implanted subcutaneously (sc) (sc)) [1]
Doses: 50 mg/kg Route of Administration: IP; BID, for 31 days (single injection of tumor site) 10 Gy local radiation exposure) Experimental Results: Dramatically inhibited tumor growth. |
| References |
| Molecular Formula |
C15H22CLN5O4S
|
|---|---|
| Molecular Weight |
403.88
|
| Exact Mass |
403.108
|
| CAS # |
2687222-59-7
|
| PubChem CID |
156824020
|
| Appearance |
White to off-white solid powder
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
9
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
26
|
| Complexity |
543
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C1C(=CC2N=CN=C(N3CCCN(S(=O)(=O)N)CC3)C=2C=1)OC)C.Cl
|
| InChi Key |
QUKMVZAYVWFICZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H21N5O4S.ClH/c1-23-13-8-11-12(9-14(13)24-2)17-10-18-15(11)19-4-3-5-20(7-6-19)25(16,21)22;/h8-10H,3-7H2,1-2H3,(H2,16,21,22);1H
|
| Chemical Name |
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide;hydrochloride
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~9.62 mg/mL (~23.82 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 10 mg/mL (24.76 mM) in 50% PEG300 +50% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4760 mL | 12.3799 mL | 24.7598 mL | |
| 5 mM | 0.4952 mL | 2.4760 mL | 4.9520 mL | |
| 10 mM | 0.2476 mL | 1.2380 mL | 2.4760 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
