| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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Elemicin is an naturally occuring alkenylbenzene widely found in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity.
| ln Vitro |
In HepG2 cells, the IC50 value of emicin (62.5, 125, 250, 500, and 1000 μM) is 910 μM [2].
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|---|---|
| ln Vivo |
Mice's liver function is impaired by elevicin (500 mg/kg; gavaged every 24 hours for 3 weeks). An imbalance in lysophospholipid choline (LPC) results from elevicin's multiplication of the SCD1 axis [3].
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| Animal Protocol |
Animal/Disease Models: Male 20-22 g wild-type C57BL/6J mice [3]
Doses: 500 mg/kg suspended in 0.5% CMC-Na Route of Administration: po (oral gavage); once every 24 hrs (hrs (hours)) for 3 weeks Experimental Results: Liver weight increased Dramatically, plasma and liver TG levels increased, and plasma total GSH and GSSG diminished. |
| References |
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| Additional Infomation |
Elemicin is an olefinic compound.
Elemicin has been reported in Daphne genkwa, Perilla frutescens, and other organisms with data available. |
| Molecular Formula |
C12H16O3
|
|---|---|
| Molecular Weight |
208.2536
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| Exact Mass |
208.11
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| CAS # |
487-11-6
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| PubChem CID |
10248
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.011 g/cm3
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| Boiling Point |
279.8ºC at 760 mmHg
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| Flash Point |
92.6ºC
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| Vapour Pressure |
0.00666mmHg at 25°C
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| Index of Refraction |
1.496
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| LogP |
2.44
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
15
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| Complexity |
179
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C([H])([H])[H])C1=C(C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])=C([H])[H])OC([H])([H])[H]
|
| InChi Key |
BPLQKQKXWHCZSS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H16O3/c1-5-6-9-7-10(13-2)12(15-4)11(8-9)14-3/h5,7-8H,1,6H2,2-4H3
|
| Chemical Name |
1,2,3-trimethoxy-5-prop-2-enylbenzene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~480.19 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.00 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (12.00 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.00 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8019 mL | 24.0096 mL | 48.0192 mL | |
| 5 mM | 0.9604 mL | 4.8019 mL | 9.6038 mL | |
| 10 mM | 0.4802 mL | 2.4010 mL | 4.8019 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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