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    Edoxaban tosylate monohydrate (DU-176b)
    Edoxaban tosylate monohydrate (DU-176b)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0950
    CAS #: 1229194-11-9Purity ≥98%

    Description: Edoxaban tosylate monohydrate (also known as DU-176b) is a potent, selective, orally bioavailable factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is used as an anticoagulant drug. Edoxaban acts as a direct factor Xa inhibitor. It was developed by Daiichi Sankyo and was approved in July 2011 in Japan for prevention of venous thromboembolisms (VTE) following lower-limb orthopedic surgery. It was also approved by the FDA in January 2015 for the prevention of stroke and non–central-nervous-system systemic embolism. 

    References: J Thromb Haemost. 2008 Sep;6(9):1542-9.

    Related CAS #: 480449-71-6 (tosylate); 480448-29-1 (HCl); 1229194-11-9 (tosylate hydrate); 480449-70-5 (free base)

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    Molecular Weight (MW)738.27
    CAS No.1229194-11-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (135.5 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    SMILES CodeO=C(NC1=NC=C(Cl)C=C1)C(N[[email protected]@H]2[[email protected]](NC(C(S3)=NC4=C3CN(C)CC4)=O)C[[email protected]@H](C(N(C)C)=O)CC2)=O.CC5=CC=C(S(=O)(O)=O)C=C5.[H]O[H]
    SynonymsDU-176b;  DU176b; DU 176b; Edoxaban; DU-176; DU 176; DU176; Edoxaban tosylate monohydrate, trade name Lixiana.

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    In Vitro

    In vitro activity: In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively.

    Cell Assay: Edoxaban tosylate monohydrate (DU-176b) inhibited FXa with Ki values of 0.561 nM for free FXa, 2.98 nM for prothrombinase, and exhibited >10 000-fold selectivity for FXa. DU-176b doubled prothrombin time and activated partial thromboplastin time in human plasma. DU-176b did not impair platelet aggregation by ADP, collagen or U46619 .

    In VivoOral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models.
    Animal modelVenous stasis thrombosis model in rats and rabbits
    Formulation & DosageDissolved in 0.5% methylcellulose;  0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat); oral gavage

    J Thromb Haemost. 2008 Sep;6(9):1542-9.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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