| Size | Price | Stock | Qty |
|---|---|---|---|
| 10g |
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| Other Sizes |
Purity: ≥98%
| Targets |
Edetol does not have a biological target; it is an industrial chemical. It can act as a chelating agent, binding to metal ions. It is used as a catalyst in manufacturing urethane foams and as an epoxy resin curing agent. It is also used as a complexing agent, humectant, plasticizer, and viscosity modifier.
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|---|---|
| ln Vitro |
According to the findings, macrophages cultured with Quadrol at concentrations of 0.5 mM, 1 mM, and 4 mM exhibited identical vitality as the control group. The viability was only 50% of the control at doses between 16 and 32 mM. Compared to the control, which caused 28% diffusion enhancement, Quadrol provided 88% and 80% diffusion enhancement at 1 mM and 4 mM doses, respectively, after four hours. Four hours later, a sixteen milligram concentration of quadrol demonstrated a % reduction in macrophage spreading. Macrophages exposed to 1.0 mM or 4.0 mM Quadrol concentrations showed a 41% and 57% increase in phagocytic activity, respectively, when compared to cells exposed to culture media (34%).
Edetol is not a biologically active compound with inhibitory or stimulatory effects. Its utility lies in its chemical properties as a tetrafunctional amine and alcohol. It is used in the production of polyurethane coatings and adhesives. It can act as a chelating agent. It is also used as a surfactant solubilizer and viscosity modifier. |
| ln Vivo |
After eight days of implantation, the normal mice's implants treated with Quadrol had a collagen content that was about 200% greater than the control group's (p<0.025). After two weeks (the amount of time normally needed for a normal and full healing of the wound), the collagen content in the implant Accumulation of the Quadrol-treated mice was about 50% higher than that of the control group (p<0.1). By day eleven, the collagen content had increased to more than 300% higher than that of the control group (p<0.01). Collagen buildup in the implants of STZ diabetic mice treated with Quadrol was almost 100% more on days 8 to 11 than in the untreated diabetic control group. Collagen deposition surpassed controls by 200% by day 14 (p<0.0 5). 2].
Edetol has no inherent in vivo biological activity. It is not used as a therapeutic agent. Its utility in biological research may include use as a chelating agent in buffer systems or as a component in certain formulations. However, it is primarily an industrial chemical and is not intended for in vivo biological applications. |
| Enzyme Assay |
There are no enzyme/receptor binding assays for Edetol as it is not a drug targeting a biological receptor. Its chelating properties can be assessed by measuring its ability to bind metal ions using spectrophotometric or potentiometric methods. Its reactivity as a curing agent can be assessed by monitoring polymerization reactions.
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| Cell Assay |
There are no cellular assays for Edetol as it is not a biologically active compound. It may be used in cell culture as a chelating agent or in buffer systems. Cytotoxicity may be assessed if the compound is used in contact with cells. However, it is primarily an industrial chemical and is not intended for cell-based assays.
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| Animal Protocol |
There are no in vivo animal studies for Edetol as a therapeutic agent. It is an industrial chemical. Toxicological studies have been conducted for occupational exposure and environmental safety. It is used as an anti-bloating agent for cattle. Its safety for human use is evaluated in the context of cosmetics and personal care products.
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| ADME/Pharmacokinetics |
Edetol has molecular weight of 292.42 g/mol and molecular formula C14H32N2O4. It is a viscous liquid. It is soluble in water. It is typically stored at room temperature. It is hygroscopic. It is used as an industrial chemical and is not intended for pharmaceutical applications.
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| Toxicity/Toxicokinetics |
Edetol is considered to have low acute toxicity. However, it may cause skin and eye irritation. Inhalation may cause respiratory irritation. Chronic exposure may have unknown effects. It is not intended for human therapeutic use. Standard industrial hygiene practices should be followed when handling this compound. It is not a drug and is not approved for therapeutic use.
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| References |
[1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12.
[2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22 |
| Additional Infomation |
Tetra(2-hydroxypropyl)ethylenediamine is an amino alcohol.
Edetol (Quadrol®) is a tertiary amine with four hydroxyl groups. It is used in polyurethane coatings, adhesives, cosmetics, and personal care products. It acts as a chelating agent, catalyst, and curing agent. It is an industrial chemical, not a therapeutic agent. |
| Molecular Formula |
C14H32N2O4
|
|---|---|
| Molecular Weight |
292.42
|
| Exact Mass |
292.236
|
| CAS # |
102-60-3
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| Related CAS # |
68258-71-9 (monotosylate)
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| PubChem CID |
7615
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| Appearance |
VISCOUS LIQUID
WATER-WHITE LIQUID |
| Density |
1.1±0.1 g/cm3
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| Boiling Point |
369.1±0.0 °C at 760 mmHg
|
| Melting Point |
32°C
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| Flash Point |
145.7±17.4 °C
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| Vapour Pressure |
0.0±1.8 mmHg at 25°C
|
| Index of Refraction |
1.517
|
| LogP |
0.13
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
11
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| Heavy Atom Count |
20
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| Complexity |
199
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])O[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])O[H])C([H])([H])C([H])(C([H])([H])[H])O[H]
|
| InChi Key |
NSOXQYCFHDMMGV-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H32N2O4/c1-11(17)7-15(8-12(2)18)5-6-16(9-13(3)19)10-14(4)20/h11-14,17-20H,5-10H2,1-4H3
|
| Chemical Name |
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
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| Synonyms |
NSC-369219; NSC 369219; Edetol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol : ~100 mg/mL (~341.99 mM)
DMSO : ~100 mg/mL (~341.99 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4197 mL | 17.0987 mL | 34.1974 mL | |
| 5 mM | 0.6839 mL | 3.4197 mL | 6.8395 mL | |
| 10 mM | 0.3420 mL | 1.7099 mL | 3.4197 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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