| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
No specific molecular target. It is a natural product and chemical repellent.
|
|---|---|
| ln Vitro |
The primary in vitro activity of cinnamamide is as a chemical repellent. (E)-Cinnamamide is the less active isomer compared to other cinnamamide isomers. Its activity is assessed in behavioral assays with birds.
|
| ln Vivo |
In vivo, cinnamamide is effective as a non-lethal chemical repellent for reducing avian pest damage. Its efficacy is demonstrated in field and aviary studies where it deters birds from feeding on treated crops.
|
| Enzyme Assay |
In vitro assays for repellent activity typically involve two-choice feeding tests with birds. The compound is incorporated into a food source, and the consumption of treated vs. untreated food is measured. The EC₅₀ for repellency can be determined.
|
| Cell Assay |
Cellular assays are not standard for this compound, as its primary application is as a repellent, not a drug.
|
| Animal Protocol |
In vivo efficacy is evaluated in field or aviary studies. Birds are presented with a choice between treated and untreated food sources, and the reduction in consumption of the treated food is measured.
|
| ADME/Pharmacokinetics |
As a small, lipophilic amide, it is expected to be absorbed if ingested. Its pharmacokinetics are not a primary focus, as it is used as a repellent. It is soluble in DMSO and ethanol but insoluble in water.
|
| Toxicity/Toxicokinetics |
Specific toxicological data is not provided. However, its use as a non-lethal repellent suggests it is of low acute toxicity to birds. As with all research chemicals, standard safety precautions should be observed. It is not intended for human therapeutic use.
|
| References | |
| Additional Infomation |
Cinnamamide is the simplest member of the cinnamamide class, consisting of an acrylamide molecule with a phenyl substituent attached at the 3-position. It has been reported to exist in plants of the Kaempferiaceae family (Aristolochia kaempferi), Reseda luteola, and other organisms with relevant data. See also: 2-acrylamide, 3-phenyl- (note moved to).
Cinnamamide derivatives exhibit therapeutic potential in animal models of central and peripheral nervous system disorders. (E)-Cinnamamide is a research chemical. |
| Molecular Formula |
C₉H₉NO
|
|---|---|
| Molecular Weight |
147.17
|
| Exact Mass |
147.068
|
| CAS # |
22031-64-7
|
| PubChem CID |
5273472
|
| Appearance |
Light brown to brown solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
350.3±25.0 °C at 760 mmHg
|
| Melting Point |
148-150ºC(lit.)
|
| Flash Point |
165.6±23.2 °C
|
| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.614
|
| LogP |
1.35
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
11
|
| Complexity |
157
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC=C(C=C1)/C=C/C(=O)N
|
| InChi Key |
APEJMQOBVMLION-VOTSOKGWSA-N
|
| InChi Code |
InChI=1S/C9H9NO/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H2,10,11)/b7-6+
|
| Chemical Name |
(E)-3-phenylprop-2-enamide
|
| Synonyms |
(E)Cinnamamide; (E) Cinnamamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~679.49 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.7949 mL | 33.9743 mL | 67.9486 mL | |
| 5 mM | 1.3590 mL | 6.7949 mL | 13.5897 mL | |
| 10 mM | 0.6795 mL | 3.3974 mL | 6.7949 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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