| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 25mg |
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| 100mg |
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| 250mg | |||
| Other Sizes |
| ADME/Pharmacokinetics |
Eicosapentaenoic acid 22n-3 (DPA n-3) is a long-chain ω-3 polyunsaturated fatty acid (PUFA) that can be endogenously synthesized in the human body from α-linolenic acid (ALA, 18:3n-3) through a series of desaturation and elongation reactions. It can also be obtained exogenously through dietary sources, with the highest content found in marine oils (such as fish oil and seal oil) [1]. In human tissues, 22n-3 eicosapentaenoic acid (DPA n-3) is mainly distributed in cell membranes, especially in the liver, brain, and adipose tissue. It is integrated into phospholipids, triglycerides, and cholesterol esters, which help maintain the fluidity and structure of cell membranes [1].
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| References | |
| Additional Infomation |
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid (C22) is a fully cis isomer of a C22 polyunsaturated fatty acid, with a double bond at positions 7, 10, 13, 16, and 19. It is a metabolite in both humans and algae. It is a C22 polyunsaturated fatty acid and also an omega-3 fatty acid. It is the conjugate acid of (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid. C22 polyunsaturated fatty acid has been reported in Homo sapiens and Caenorhabditis elegans, and relevant data are available. Krupanoic acid is a polyunsaturated, ultra-long-chain fatty acid with a 22-carbon backbone and 5 double bonds located at positions 3, 6, 9, 12, and 15 of the methyl terminus. All double bonds are in the cis configuration. Eicosapentaenoic acid (DEPA) has three known isomers, with its double bond located at positions 3, 6, 9, 12 and 15 from the methyl terminus, positions 3, 7, 10, 14 and 18, or positions 6, 9, 12, 15 and 18.
Eicosapentaenoic acid 22n-3 (DPA n-3) is classified as an essential ω-3 fatty acid, with a chemical structure of 22 carbon atoms containing 5 cis double bonds, the first of which is located on the 3rd carbon atom from the methyl terminus of the fatty acid chain[1]. It is closely related to the metabolism of other important ω-3 polyunsaturated fatty acids (such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), etc.). DHA is both a precursor to DHA synthesis and an independent component of the cell membrane. It is synthesized from ALA and is regulated by desaturases (Δ6, Δ5 desaturases) and elongation enzymes[1]. Eicosapentaenoic acid 22n-3 (DPA n-3) is an essential fatty acid that is crucial for normal physiological functions in the human body, including maintaining membrane structure, lipid metabolism and regulating inflammatory responses. Due to the lack of an enzyme that introduces a double bond after the 9th carbon atom at the end of the carboxyl group, the human body cannot synthesize DPA n-3 de novo, so it must be obtained through dietary intake or synthesized endogenously by ALA[1]. |
| Molecular Formula |
C22H34O2
|
|---|---|
| Molecular Weight |
330.50416
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| Exact Mass |
330.255
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| CAS # |
24880-45-3
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| PubChem CID |
5497182
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
442.2±24.0 °C at 760 mmHg
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| Flash Point |
338.9±18.0 °C
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| Vapour Pressure |
0.0±2.3 mmHg at 25°C
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| Index of Refraction |
1.509
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| LogP |
7.26
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
24
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| Complexity |
425
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCCC(O)=O
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| InChi Key |
YUFFSWGQGVEMMI-JLNKQSITSA-N
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| InChi Code |
InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
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| Chemical Name |
(7Z,10Z,13Z,16Z,19Z)-docosa-7,10,13,16,19-pentaenoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~151.29 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (7.56 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (7.56 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0257 mL | 15.1286 mL | 30.2572 mL | |
| 5 mM | 0.6051 mL | 3.0257 mL | 6.0514 mL | |
| 10 mM | 0.3026 mL | 1.5129 mL | 3.0257 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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