| Size | Price | Stock | Qty |
|---|---|---|---|
| 5g |
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| Other Sizes |
| Targets |
DL-Lysine does not have a specific therapeutic target but serves as a fundamental building block for proteins and a precursor for various metabolites. L-Lysine is the biologically active form and is utilized by the body for protein synthesis and the production of other compounds. As a racemic mixture, DL-Lysine contains both the active L-form and the inactive D-form. The D-enantiomer is not incorporated into proteins and is primarily used in research. In animal nutrition, DL-Lysine is a common supplement to ensure adequate dietary intake of this essential amino acid.
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|---|---|
| ln Vitro |
D-lysine is created from L-lysine through continuous chemical racemization and microbial asymmetric breakdown. L-lysine is the enantiomer of D-lysine. D-Lysine is found in all species from bacteria to humans. D-Lysine is a potentially hazardous chemical [1].
In vitro, DL-Lysine is used as a supplement in cell culture media to support cell growth and protein synthesis. It is an essential nutrient for most mammalian cell lines. The compound is also used as a reference standard in analytical chemistry and as a building block in peptide synthesis. Its primary activity is as a nutrient, not as a pharmacologically active compound with a specific potency. |
| ln Vivo |
In vivo, L-Lysine is an essential amino acid that is critical for growth, tissue repair, and immune function. It is a precursor for the synthesis of carnitine, which is essential for fatty acid oxidation and energy production. Lysine also plays a role in calcium absorption and collagen formation. A deficiency of lysine can lead to growth retardation, impaired immune function, and other health problems. DL-Lysine is used as a dietary supplement in animal feed to improve growth performance.
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| Enzyme Assay |
In vitro non-cell enzyme/receptor binding assays are not applicable for DL-Lysine, as it is a nutrient. Its properties are typically assessed using analytical techniques such as HPLC or amino acid analysis to determine its purity and concentration. Its role as a substrate for lysine-metabolizing enzymes, such as lysine dehydrogenase, can be studied in enzyme assays.
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| Cell Assay |
In vitro cell-based assays for DL-Lysine are used to study its effects on cell growth and metabolism. Cells are cultured in media containing varying concentrations of lysine, and parameters such as cell proliferation, protein synthesis, and gene expression are assessed. These studies help to elucidate the role of lysine in cellular function and metabolism.
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| Animal Protocol |
In vivo animal studies for DL-Lysine are primarily nutritional studies conducted to determine the lysine requirements of various animal species. Animals are fed diets with varying levels of lysine, and growth performance, feed efficiency, and nitrogen balance are measured. These studies are essential for formulating balanced diets for livestock and poultry.
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| ADME/Pharmacokinetics |
DL-Lysine has a molecular weight of 146.19 g/mol and a molecular formula of C₆H₁₄N₂O₂. It is a white to off-white crystalline powder or granules. The compound is soluble in water, slightly soluble in ethanol, and insoluble in ether. It has a melting point of approximately 170°C (dec.). It is hygroscopic and should be stored in a cool, dry place, protected from moisture.
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| Toxicity/Toxicokinetics |
DL-Lysine is generally recognized as safe (GRAS) when used as a nutritional supplement. It is non-toxic at normal dietary levels. However, excessive intake may cause gastrointestinal distress. The compound is not intended for therapeutic use as a drug. Standard laboratory safety precautions should be followed when handling the compound.
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| References | |
| Additional Infomation |
Lysine is a diamino acid, a form of hexanoic acid with two amino substituents at positions 2 and 6. It is a metabolite of the large flea (Daphnia magna). Lysine is an α-amino acid, a diamino acid, and a polar amino acid containing a 4-aminobutyl group. Functionally, it is related to hexanoic acid. It is the conjugate base of lysine (1+) and also the conjugate acid of lysine. DL-lysine has been reported in Drosophila melanogaster, Enterococcus faecalis, and several other organisms with relevant data. See also: fenugreek seeds (partial); lysine (note moved here).
DL-Lysine is the racemic mixture of the essential amino acid lysine. It is used in biochemical research and as a nutritional supplement. Lysine is essential for protein synthesis, hormone production, and immune function. It is not approved as a drug but is available as a dietary supplement and feed additive. |
| Molecular Formula |
C6H14N2O2
|
|---|---|
| Molecular Weight |
146.1876
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| Exact Mass |
146.105
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| CAS # |
70-54-2
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| Related CAS # |
DL-Lysine-d4 dihydrochloride;284664-88-6;DL-Lysine monohydrate;885701-25-7
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| PubChem CID |
866
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| Appearance |
White to light yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
311.5±32.0 °C at 760 mmHg
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| Melting Point |
170ºC (dec.)
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| Flash Point |
142.2±25.1 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.503
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| LogP |
-1.04
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
10
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| Complexity |
106
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C(CCN)CC(C(=O)O)N
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| InChi Key |
KDXKERNSBIXSRK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)
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| Chemical Name |
2,6-diaminohexanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~684.04 mM)
DMSO : ~1 mg/mL (~6.84 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (684.04 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.8404 mL | 34.2021 mL | 68.4041 mL | |
| 5 mM | 1.3681 mL | 6.8404 mL | 13.6808 mL | |
| 10 mM | 0.6840 mL | 3.4202 mL | 6.8404 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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