| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| Targets |
Diuron-d6 does not have a specific biological target as a drug; it is a stable isotope-labeled internal standard. The parent compound diuron is an orally active herbicide that inhibits photosynthesis in plants by blocking the formation of ATP and NADH. The deuterated version is used as a tracer for quantification.
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|---|---|
| ln Vitro |
Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may affect a drug's pharmacokinetics and metabolic properties, it is a cause for concern [75].
Diuron-d6 is not evaluated for in vitro biological activity as a drug; it is a stable isotope-labeled internal standard. The parent compound is a herbicide. The labeled version is used for analytical purposes and does not have intrinsic pharmacological activity. |
| ln Vivo |
Diuron-d6 is not administered as a therapeutic agent and does not have intrinsic in vivo pharmacological activity. It is used as an internal standard for the quantification of diuron.
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| Enzyme Assay |
There are no specific in vitro enzyme or receptor binding assays for Diuron-d6 as a drug target. As an internal standard, it is used in analytical chemistry. The compound is characterized by its isotopic purity.
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| Cell Assay |
There are no specific in vitro cellular assays for Diuron-d6 as a pharmacologically active compound. As an internal standard, it is used in sample preparation for GC-MS or LC-MS analysis.
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| Animal Protocol |
There are no specific in vivo animal studies for Diuron-d6 as a pharmacologically active compound. As an internal standard, it is used in the analysis of biological samples.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of Diuron-d6 are not studied as a drug; it is an analytical internal standard. The labeled compound has similar physicochemical properties to diuron. It is typically used in trace amounts for analytical purposes.
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| Toxicity/Toxicokinetics |
The toxicity profile of Diuron-d6 is not reported, as it is a stable isotope-labeled research compound used in trace amounts. The parent compound is a herbicide, but the labeled version is not used for therapeutic purposes.
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| References | |
| Additional Infomation |
Diuron-d6 is a stable isotope-labeled version of the herbicide diuron, used as an internal standard for environmental and pharmacokinetic studies. It has a molecular weight of 239.13. The compound is available for research purposes only.
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| Molecular Formula |
C9H4CL2D6N2O
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|---|---|
| Molecular Weight |
239.13100
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| Exact Mass |
238.054
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| CAS # |
1007536-67-5
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| Related CAS # |
Diuron;330-54-1
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| PubChem CID |
16212191
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
385.2±42.0 °C at 760 mmHg
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| Melting Point |
147-150?C
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| Flash Point |
186.7±27.9 °C
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| Vapour Pressure |
0.0±0.9 mmHg at 25°C
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| Index of Refraction |
1.606
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| LogP |
2.78
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
14
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| Complexity |
211
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| Defined Atom Stereocenter Count |
0
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| SMILES |
[2H]C([2H])(N(C(NC1=CC(Cl)=C(Cl)C=C1)=O)C([2H])([2H])[2H])[2H]
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| InChi Key |
XMTQQYYKAHVGBJ-WFGJKAKNSA-N
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| InChi Code |
InChI=1S/C9H10Cl2N2O/c1-13(2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)/i1D3,2D3
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| Chemical Name |
3-(3,4-dichlorophenyl)-1,1-bis(trideuteriomethyl)urea
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ≥ 100 mg/mL (~418.2 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.45 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1818 mL | 20.9091 mL | 41.8183 mL | |
| 5 mM | 0.8364 mL | 4.1818 mL | 8.3637 mL | |
| 10 mM | 0.4182 mL | 2.0909 mL | 4.1818 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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