| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
Disperse Red 1 at concentrations of 1.0 and 2.0 μg/mL caused mutations in the Salmonella assay (13 revertants/μg) and an increase in the frequency of micronuclei in human lymphocytes and human hepatoma (HepG2) cell lines when they were exposed in vitro [2].
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| ln Vivo |
Male, sexually mature mice (Mus musculus, strain CF-1) were given a single oral dose (20–500 mg/kg) of Disperse Red 1 (DR1) to assess the compound's reproductive toxic effects. Testicular toxicity, an increase in the frequency of sperm with aberrant morphology, and decreased fertility are all effects of the Disperse Red 1 treatment. Testicular cells treated with 100 and 500 mg/kg for 16.6 and 24.9 days showed increased amounts of DNA damage [2].
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| References | |
| Additional Infomation |
Disperse Red 1 is an azo dye with a structure consisting of nitrobenzene substituted on the 4-position of the phenyl group with a 4-[N-ethyl-N-(2-hydroxyethyl)]phenylazo group. It has a role as a dye and an allergen. It is a monoazo compound and a member of azobenzenes. It is functionally related to an azobenzene.
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| Molecular Formula |
C16H18N4O3
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|---|---|
| Molecular Weight |
314.33912
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| Exact Mass |
314.138
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| CAS # |
2872-52-8
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| PubChem CID |
17886
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| Appearance |
Brown to black solid powder
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| Density |
1.23 g/cm3
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| Boiling Point |
522.5ºC at 760 mmHg
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| Melting Point |
160-162 °C(lit.)
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| Flash Point |
269.8ºC
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| Vapour Pressure |
9.57E-12mmHg at 25°C
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| Index of Refraction |
1.602
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| LogP |
4.352
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
23
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| Complexity |
383
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FOQABOMYTOFLPZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H18N4O3/c1-2-19(11-12-21)15-7-3-13(4-8-15)17-18-14-5-9-16(10-6-14)20(22)23/h3-10,21H,2,11-12H2,1H3
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| Chemical Name |
2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~83.33 mg/mL (~265.10 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1813 mL | 15.9063 mL | 31.8127 mL | |
| 5 mM | 0.6363 mL | 3.1813 mL | 6.3625 mL | |
| 10 mM | 0.3181 mL | 1.5906 mL | 3.1813 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02498886 | Completed | Dietary Supplement: IHAT Dietary Supplement: Ferrous sulphate |
Iron-deficiency Anemia | Medical Research Council | August 2015 | Early Phase 1 |
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