| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
Disperse Red 1 does not have a defined biological target as it is a textile dye rather than a pharmaceutical agent. It is used for its coloring properties in textile dyeing and as a non-linear optical material. Its mechanism of action is physical, based on its ability to absorb light and its azobenzene chromophore properties.
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| ln Vitro |
Disperse Red 1 at concentrations of 1.0 and 2.0 μg/mL caused mutations in the Salmonella assay (13 revertants/μg) and an increase in the frequency of micronuclei in human lymphocytes and human hepatoma (HepG2) cell lines when they were exposed in vitro [2].
Disperse Red 1 is not a bioactive compound with defined pharmacological activity. Its in vitro activity is related to its use as a textile dye and as a non-linear optical material. The compound is used in dyeing and printing polyester and blended fabrics. It is also used in materials science for its optical properties. |
| ln Vivo |
Male, sexually mature mice (Mus musculus, strain CF-1) were given a single oral dose (20–500 mg/kg) of Disperse Red 1 (DR1) to assess the compound's reproductive toxic effects. Testicular toxicity, an increase in the frequency of sperm with aberrant morphology, and decreased fertility are all effects of the Disperse Red 1 treatment. Testicular cells treated with 100 and 500 mg/kg for 16.6 and 24.9 days showed increased amounts of DNA damage [2].
Disperse Red 1 is not used as a therapeutic agent and does not have defined in vivo pharmacological activity. However, it has been shown to cause testicular toxicity in animal studies, increasing the frequency of sperm with abnormal morphology and decreasing fertility. Its applications are limited to textile dyeing and materials science. |
| Enzyme Assay |
In vitro assays for Disperse Red 1 are not typically performed as it is not a drug. However, its optical properties can be characterized by UV-Vis spectroscopy to measure absorption spectra. The compound's azobenzene chromophore can undergo photoisomerization, which can be studied using spectroscopic techniques.
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| Cell Assay |
Cell-based assays are not applicable for Disperse Red 1 as it is not a bioactive compound. The compound is used as a textile dye and in materials science applications. It is not intended for use in cellular assays or as a therapeutic agent. Toxicity studies may be performed using cell culture to assess cytotoxic effects.
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| Animal Protocol |
In vivo animal studies for Disperse Red 1 have been conducted to assess its toxicological effects. Studies have shown that Disperse Red 1 treatment causes testicular toxicity, increases the frequency of sperm with abnormal morphology, and decreases fertility in animal models. These studies are typically conducted as part of safety evaluations for occupational exposure.
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| ADME/Pharmacokinetics |
Disperse Red 1 has a molecular weight of 314.34 g/mol and a molecular formula of C16H18N4O3. Its IUPAC name is 2-[N-ethyl-4-[(E)-(4-nitrophenyl)diazenyl]anilino]ethanol. The compound is water-insoluble and appears as a dark red powder. It is soluble in organic solvents and should be stored under dry conditions.
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| Toxicity/Toxicokinetics |
Disperse Red 1 has been shown to cause testicular toxicity, increase the frequency of sperm with abnormal morphology, and decrease fertility in animal studies. The compound may be toxic to the reproductive system. It should be handled with appropriate safety precautions in occupational settings. It is not intended for human therapeutic use.
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| References | |
| Additional Infomation |
Disperse Red 1 is an azo dye with a nitrobenzene structure, where the benzene ring at position 4 is replaced by a 4-[N-ethyl-N-(2-hydroxyethyl)]phenylazo group. It is both a dye and a sensitizer. It is a monoazo compound, belonging to the azobenzene class of compounds. Its function is similar to that of azobenzene.
Disperse Red 1 is an azo disperse dye used for dyeing polyester and acetate fibers and as a non-linear optical material. It has been shown to cause testicular toxicity in animal studies. The compound is not a therapeutic agent and is intended for textile dyeing and research applications only. |
| Molecular Formula |
C16H18N4O3
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|---|---|
| Molecular Weight |
314.33912
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| Exact Mass |
314.138
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| CAS # |
2872-52-8
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| PubChem CID |
17886
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| Appearance |
Brown to black solid powder
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| Density |
1.23 g/cm3
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| Boiling Point |
522.5ºC at 760 mmHg
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| Melting Point |
160-162 °C(lit.)
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| Flash Point |
269.8ºC
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| Vapour Pressure |
9.57E-12mmHg at 25°C
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| Index of Refraction |
1.602
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| LogP |
4.352
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
23
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| Complexity |
383
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
FOQABOMYTOFLPZ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H18N4O3/c1-2-19(11-12-21)15-7-3-13(4-8-15)17-18-14-5-9-16(10-6-14)20(22)23/h3-10,21H,2,11-12H2,1H3
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| Chemical Name |
2-[N-ethyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~83.33 mg/mL (~265.10 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1813 mL | 15.9063 mL | 31.8127 mL | |
| 5 mM | 0.6363 mL | 3.1813 mL | 6.3625 mL | |
| 10 mM | 0.3181 mL | 1.5906 mL | 3.1813 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02498886 | Completed | Dietary Supplement: IHAT Dietary Supplement: Ferrous sulphate |
Iron-deficiency Anemia | Medical Research Council | August 2015 | Early Phase 1 |
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