Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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Other Sizes |
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Purity: ≥98%
Dimesna (also called BNP-7787) is an uroprotective agent used to decrease urotoxicity caused by anticancer drugs such cisplatin. It reacts with acrolein and other urotoxic metabolites of oxazaphosphorine class of antitumor drugs such as cyclophosphamide or ifosfamide to form stable, non-urotoxic compounds.Dimesna modulates paclitaxel-induced hyperpolymerization of MTP in a dose-dependent manner, and mesna, an in vivo metabolite of Dimesna, protects against time-dependent cisplatin-induced inactivation of MTP. Dimesna -mediated prevention or mitigation of cisplatin-induced nephrotoxicity may involve aminopeptidase N (APN) inhibition by certain Dimesna -derived esna-disulfide heteroconjugates and appears correlated to the presence of a glycinate moiety and/or an anionic group.
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ln Vivo |
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Animal Protocol |
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References |
Mol Cancer Ther.2010 Sep;9(9):2558-67;Cancer Chemother Pharmacol.2010 Apr;65(5):941-51.
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Molecular Formula |
C4H8NA2O6S4
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Molecular Weight |
326.34
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CAS # |
16208-51-8
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Related CAS # |
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SMILES |
S(C([H])([H])C([H])([H])SSC([H])([H])C([H])([H])S(=O)(=O)[O-])(=O)(=O)[O-].[Na+].[Na+]
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.0643 mL | 15.3214 mL | 30.6429 mL | |
5 mM | 0.6129 mL | 3.0643 mL | 6.1286 mL | |
10 mM | 0.3064 mL | 1.5321 mL | 3.0643 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.